Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (PubMed:24316148, PubMed:24407481). Acts redundantly with agtrl1b in heart development.
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Protein Aliases: Angiotensin II receptor-like 1a; angiotensin receptor-like 1; Angiotensin receptor-like 1a; Apelin receptor A; G-protein coupled receptor APJ A
Gene Aliases: Agtr1; agtrl1; agtrl1a; aplnra; msr; zgc:152843
Entrez Gene ID: (Zebrafish) 561935