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Invitrogen
APLP1 Polyclonal Antibody
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FIGURE: 1 / 2
APLP1 Antibody (PA5-48028) in IHC (P)
Immunohistochemical analysis of APLP1 in immersion fixed paraffin-embedded sections of human brain (cortex). Samples were incubated with APLP1 polyclonal antibody (Product # PA5-48028) using a dilution of 0.3 µg/mL for 1 hour at room temperature followed by Anti-Goat IgG VisUCyte™ HRP Polymer Antibody. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using ... View More
Product Details
PA5-48028
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human APLP-1 Gln34-Glu580
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, approximately 15% cross-reactivity with recombinant mouse APLP-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amyloid beta (A4) precursor-like protein 1; Amyloid beta precursor like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; APLPAPLP-1; unnamed protein product
Gene Aliases: APLP; APLP1
UniProt ID: (Human) P51693
Entrez Gene ID: (Human) 333
regulation of translation
endocytosis
apoptotic process
cell adhesion
nervous system development
axonogenesis
central nervous system development
organ morphogenesis
extracellular matrix organization
forebrain development
animal organ development
cellular response to norepinephrine stimulus
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
cytosolic mRNA polyadenylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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