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Product Details
PA5-48028
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.1 µg/mL | - |
Immunohistochemistry (IHC) |
0.3-15 µg/mL | - |
Immunoprecipitation (IP) |
25 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Goat / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Mouse myeloma cell line NS0-derived recombinant human APLP-1 Gln34-Glu580 |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS with 5% trehalose |
Contains |
No Preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2608602 |
Product Specific Information
In Western blots, approximately 15% cross-reactivity with recombinant mouse APLP-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amyloid beta (A4) precursor-like protein 1; Amyloid beta precursor like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; APLPAPLP-1; C30
Gene Aliases: APLP; APLP1
UniProt ID: (Human) P51693
Entrez Gene ID: (Human) 333
Molecular Function:
protease inhibitor
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