In Western blots, approximately 15% cross-reactivity with recombinant mouse APLP-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
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Protein Aliases: amyloid beta (A4) precursor-like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; APLPAPLP-1; C30
Gene Aliases: APLP; APLP1
UniProt ID: (Human) P51693
Entrez Gene ID: (Human) 333
Molecular Function: protease inhibitor