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Invitrogen
APLP1 Polyclonal Antibody
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FIGURE: 1 / 4
APLP1 Antibody (PA5-78795) in IHC (P)
Immunohistochemistry analysis of APLP1 on paraffin-embedded mouse brain tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with APLP1 polyclonal antibody (Product# PA5-78795) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Developm... View More
Product Details
PA5-78795
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human APLP1 (82-112aa RRCLRDPQRVLEYCRQMYPELQIARVEQATQ).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Brain Tissue, Rat Testis Tissue, SGC whole cell, 22RV1 whole cell, MCF-7 whole cell. IHC: Mouse Brain tissue, Rat Brain tissue. Flow: SiHa cell.
Target Information
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amyloid beta (A4) precursor-like protein 1; Amyloid beta precursor like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; APLP-1; APLPAPLP-1
Gene Aliases: APLP; APLP1; Aplp1_retired; RGD1561211
UniProt ID: (Human) P51693, (Mouse) Q03157
Entrez Gene ID: (Human) 333, (Rat) 502317, (Mouse) 11803
endocytosis
apoptotic process
cell adhesion
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
nervous system development
organ morphogenesis
negative regulation of cAMP biosynthetic process
cellular response to norepinephrine stimulus
mRNA polyadenylation
regulation of translation
extracellular matrix organization
forebrain development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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