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Proteintech
APOB Polyclonal Antibody
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Product Details
20578-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes both of ApoB-48 and ApoB-100.
Target Information
Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearance of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. MDA-oxidized LDL appear to be different from LDL oxidized by other means. Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in the Apolipoprotein B gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective Apolipoprotein B, diseases affecting plasma cholesterol and Apolipoprotein B levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apo B-100; Apo B100; apo-B; ApoB 100; ApoB 48; apolipo b; apolipoprotein B; apolipoprotein B (including Ag(x) antigen); Apolipoprotein B 100; Apolipoprotein B 48; apolipoprotein B precursor; Apolipoprotein B-100; apolipoprotein B-100 precursor; apolipoprotein B-48; Apolipoprotein B100; apolipoprotein B100 precursor; apolipoprotein B46; apolipoprotein B47; apolipoprotein B48; apolipoprotein B49; LOX-1; mCG_129875; MGC176318; Ox-LDL receptor 1; truncated apolipoprotein B-48; unnamed protein product
Gene Aliases: AI315052; Apo B-100; APOB; apoB-100; apoB-48; FCHL2; FLDB; LDLCQ4
UniProt ID: (Human) P04114, (Mouse) E9Q414
Entrez Gene ID: (Human) 338, (Mouse) 238055
in utero embryonic development
lipid metabolic process
triglyceride mobilization
lipid transport
signal transduction
spermatogenesis
nervous system development
steroid metabolic process
cholesterol metabolic process
fertilization
response to virus
post-embryonic development
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
positive regulation of lipid storage
positive regulation of cholesterol storage
lipid catabolic process
triglyceride catabolic process
cholesterol transport
sperm motility
cholesterol efflux
low-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
low-density lipoprotein particle clearance
lipoprotein metabolic process
lipoprotein biosynthetic process
lipoprotein catabolic process
cholesterol homeostasis
lipoprotein transport
regulation of cholesterol biosynthetic process
artery morphogenesis
establishment of localization in cell
cellular response to lipoprotein particle stimulus
cellular response to beta-amyloid
transport
response to carbohydrate
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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