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Invitrogen
APOBEC1 Polyclonal Antibody
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FIGURE: 1 / 1
APOBEC1 Antibody (PA5-109400) in WB
Western blot analysis of APOBEC1 in extracts of Mouse spleen. Samples were incubated with APOBEC1 Polyclonal antibody (Product # PA5-109400) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
Product Details
PA5-109400
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human APOBEC1 (NP_001291495).
Conjugate
Form
Liquid
Concentration
1.51 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MTSEKGPSTG DPTLRRRIEP WEFDVFYDPR ELRKEACLLY EIKWGMSRKI WRSSGKNTTN HVEVNFIKKF TSERDFHPSM
Target Information
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor and APOBEC1 stimulating protein . This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APOBEC-1; apolipoprotein B editing complex 1; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1; C->U-editing enzyme APOBEC-1; mRNA(cytosine(6666)) deaminase 1
Gene Aliases: Apobec1; Cdar1
UniProt ID: (Mouse) P51908
Entrez Gene ID: (Mouse) 11810
catalytic activity
GTP cyclohydrolase activity
cytidine deaminase activity
cytosine deaminase activity
protein binding
tRNA-specific adenosine deaminase activity
zinc ion binding
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
AU-rich element binding
N-cyclopropylmelamine deaminase activity
N-cyclopropylammeline deaminase activity
N-cyclopropylammelide alkylamino hydrolase activity
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
tRNA-specific adenosine-37 deaminase activity
archaeal-specific GTP cyclohydrolase activity
metal ion binding
tRNA-specific adenosine-34 deaminase activity
RNA processing factor
mRNA processing
response to osmotic stress
cytidine deamination
response to gamma radiation
cytidine to uridine editing
mRNA modification
regulation of cell proliferation
lipoprotein metabolic process
lipoprotein biosynthetic process
response to drug
lipoprotein transport
response to ethanol
mRNA stabilization
response to calcium ion
defense response to virus
DNA cytosine deamination
DNA demethylation
negative regulation of methylation-dependent chromatin silencing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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