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APOC3 Polyclonal Antibody
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Product Details
BS-4741R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human APOC3, amino acids 21-80.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-CIII; Apolipoprotein; Apolipoprotein C-III; apolipoprotein C-III precursor; Apolipoprotein C3; MGC150353; unnamed protein product
Gene Aliases: Apo-C3; apo-CIII; ApoC-3; apoC-III; APOC3; APOCIII
UniProt ID: (Human) P02656, (Mouse) P33622
Entrez Gene ID: (Human) 345, (Mouse) 11814
lipid metabolic process
triglyceride metabolic process
lipid transport
G-protein coupled receptor signaling pathway
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle remodeling
negative regulation of very-low-density lipoprotein particle clearance
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
lipid catabolic process
triglyceride catabolic process
regulation of Cdc42 protein signal transduction
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
chylomicron remnant clearance
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of cholesterol import
triglyceride homeostasis
triglyceride mobilization
transport
cholesterol metabolic process
lipoprotein transport
response to peptide hormone
cellular response to glucose stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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