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APOC3 Polyclonal Antibody
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Product Details
BS-5037R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from rat Apolipoprotein CIII, amino acids 41-80.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-CIII; Apolipoprotein; apolipoprotein C-3; Apolipoprotein C-III; Apolipoprotein C3; MGC150353
Gene Aliases: apo-CIII; ApoC-III; Apoc3
UniProt ID: (Mouse) P33622
Entrez Gene ID: (Mouse) 11814, (Rat) 24207
lipid metabolic process
triglyceride metabolic process
triglyceride mobilization
transport
lipid transport
cholesterol metabolic process
lipid catabolic process
triglyceride catabolic process
lipoprotein metabolic process
lipoprotein transport
response to peptide hormone
cellular response to glucose stimulus
inflammatory response
G-protein coupled receptor signaling pathway
response to nutrient
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle remodeling
negative regulation of very-low-density lipoprotein particle clearance
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
regulation of Cdc42 protein signal transduction
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle remodeling
chylomicron remnant clearance
response to drug
cholesterol homeostasis
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of lipoprotein lipase activity
negative regulation of cholesterol import
triglyceride homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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