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          • Primary Antibodies ›
          • APOE Antibodies

          Bioss

          APOE Polyclonal Antibody

          View all (29) APOE antibodies

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          Cite APOE Polyclonal Antibody

          APOE Polyclonal Antibody

          Product Details

          BS-0167R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from mouse Apo E, amino acids 211-311.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          PBS with 50% glycerol, 1% BSA

          Contains

          0.09% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Apo E (Apolipoprotein E) plays an important role in the metabolism of lipids in the plasma, and is also is a constituent of various plasma lipoprotein-lipid particles. The protein is synthesized in liver, brain, spleen, and the kidney, and concentrations are high in interstitial fluids, where it plays a role in distributing cholesterol from cells where cholesterol is in excess to cells which require cholesterol. Apo E also plays an important role in the formation of very low density lipoprotein and chylomicrons. The Apo E gene is located on chromosome 19 at position 19q13. 2.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Apo-E; ApoE4; Apolipoprotein; Apolipoprotein E; apolipoprotein E4; Apoprotein; B2G1; BG; MGC1571

          View more View less

          Gene Aliases: AI255918; Apo-E; Apoe; APOEA

          View more View less

          UniProt ID: (Mouse) P08226, (Rat) P02650

          View more View less

          Entrez Gene ID: (Mouse) 11816, (Rat) 25728

          View more View less

          Function(s)
          beta-amyloid binding receptor binding lipid transporter activity phospholipid binding heparin binding lipid binding cholesterol binding antioxidant activity cholesterol transporter activity identical protein binding protein homodimerization activity hydroxyapatite binding metal chelating activity tau protein binding low-density lipoprotein particle receptor binding phosphatidylcholine-sterol O-acyltransferase activator activity very-low-density lipoprotein particle receptor binding lipoprotein particle binding apolipoprotein
          Process(es)
          negative regulation of endothelial cell proliferation response to dietary excess lipid metabolic process triglyceride metabolic process cholesterol biosynthetic process cholesterol catabolic process lipid transport cellular calcium ion homeostasis receptor-mediated endocytosis response to oxidative stress G-protein coupled receptor signaling pathway nitric oxide mediated signal transduction aging protein localization cholesterol metabolic process regulation of gene expression negative regulation of platelet activation positive regulation of cholesterol esterification positive regulation of cholesterol efflux peripheral nervous system axon regeneration long-chain fatty acid transport protein import triglyceride catabolic process cGMP-mediated signaling negative regulation of blood coagulation positive regulation of cGMP biosynthetic process neuron projection regeneration axon regeneration regulation of cholesterol transport regulation of Cdc42 protein signal transduction response to retinoic acid positive regulation of low-density lipoprotein particle receptor catabolic process response to insulin cholesterol efflux phospholipid efflux very-low-density lipoprotein particle remodeling low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling high-density lipoprotein particle assembly chylomicron remnant clearance high-density lipoprotein particle clearance very-low-density lipoprotein particle clearance lipoprotein metabolic process lipoprotein biosynthetic process lipoprotein catabolic process vasodilation cholesterol homeostasis positive regulation of catalytic activity negative regulation of MAP kinase activity negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration reverse cholesterol transport response to ethanol negative regulation of cholesterol biosynthetic process positive regulation of axon extension positive regulation of lipid biosynthetic process oligodendrocyte differentiation artery morphogenesis negative regulation of inflammatory response positive regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis negative regulation of lipid biosynthetic process maintenance of location in cell lipid homeostasis fatty acid homeostasis positive regulation of dendritic spine development negative regulation of dendritic spine development cellular response to interleukin-1 cellular response to growth factor stimulus cellular response to cholesterol cardiovascular system development negative regulation of cholesterol efflux AMPA glutamate receptor clustering NMDA glutamate receptor clustering regulation of beta-amyloid clearance regulation of neuron death negative regulation of neuron death positive regulation of neuron death negative regulation of postsynaptic membrane organization positive regulation of postsynaptic membrane organization negative regulation of presynaptic membrane organization positive regulation of presynaptic membrane organization positive regulation of beta-amyloid formation negative regulation of beta-amyloid formation regulation of tau-protein kinase activity negative regulation of dendritic spine maintenance positive regulation of dendritic spine maintenance positive regulation of phospholipid efflux positive regulation of neurofibrillary tangle assembly negative regulation of phospholipid efflux negative regulation of lipid transport across blood brain barrier positive regulation of lipid transport across blood brain barrier
          It has to be done as per old AB suggested Products section.
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