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Product Details
14863-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APPBP1 Fusion Protein Ag6672 (181-534 aa encoded by BC000480)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EDLRLDKPF PELREHFQSY DLDHMEKKDH SHTPWIVIIA KYLAQWYSET NGRIPKTYKE KEDFRDLIRQ GILKNENGAP EDEENFEEAI KNVNTALNTT QIPSSIEDIF NDDRCINITK QTPSFWILAR ALKEFVAKEG QGNLPVRGTI PDMIADSGKY IKLQNVYREK AKKDAAAVGN HVAKLLQSIG QAPESISEKE LKLLCSNSAF LRVVRCRSLA EEYGLDTINK DEIISSMDNP DNEIVLYLML RAVDRFHKQQ GRYPGVSNYQ VEEDIGKLKS CLTGFLQEYG LSVMVKDDYV HEFCRYGAAE PHTIAAFLGG AAAQEVIKII TKQFVIFNNT YIYSGMSQTS ATFQL (181-534 aa encoded by BC000480)
Target Information
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: amyloid beta precursor protein binding protein 1, 59kDa; Amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid beta precursor protein-binding protein 1, 59kD; Amyloid protein-binding protein 1; APP-BP1; NEDD8-activating enzyme E1 regulatory subunit; NEDD8-activating enzyme E1 subunit; Proto-oncogene protein 1; protooncogene protein 1
Gene Aliases: 59kDa; A-116A10.1; APPBP1; HPP1; NAE1; ula-1
UniProt ID: (Human) Q13564, (Mouse) Q8VBW6
Entrez Gene ID: (Human) 8883, (Mouse) 234664, (Rat) 84019
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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