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Proteintech
APPL1 Polyclonal Antibody
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Product Details
19885-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APPL1 Fusion Protein Ag13703 (1-323 aa encoded by BC028599)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPGIDKLPI EETLEDSPQT RSLLGVFEED ATAISNYMNQ LYQAMHRIYD AQNELSAATH LTSKLLKEYE KQRFPLGGDD EVMSSTLQQF SKVIDELSSC HAVLSTQLAD AMMFPITQFK ERDLKEILTL KEVFQIASND HDAAINRYSR LSKKRENDKV KYEVTEDVYT SRKKQHQTMM HYFCALNTLQ YKKKIALLEP LLGYMQAQIS FFKMGSENLN EQLEEFLANI GTSVQNVRRE MDSDIETMQQ TIEDLEVASD PLYVPDPDPT KFPVNRNLTR KAGYLNARNK TGLVSSTWDR QFYFTQGGNL MSQARGDVAG GLAM (1-323 aa encoded by BC028599)
Target Information
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signaling and insulin signaling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein APPL like; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; AKT2 interactor; DCC-interacting protein 13-alpha; DIP13 alpha; Dip13-alpha; signaling adaptor protein DIP13alpha; unnamed protein product
Gene Aliases: 2900057D21Rik; 7330406P05Rik; AI585782; APPL; APPL1; AW209077; BB022931; C88264; DIP13; DIP13A; DIP13alpha; KIAA1428; MODY14; RGD1309388
UniProt ID: (Human) Q9UKG1, (Mouse) Q8K3H0
Entrez Gene ID: (Human) 26060, (Rat) 290537, (Mouse) 72993
protein import into nucleus
signal transduction
transforming growth factor beta receptor signaling pathway
insulin receptor signaling pathway
positive regulation of biosynthetic process
regulation of fibroblast migration
signaling
adiponectin-activated signaling pathway
regulation of toll-like receptor 4 signaling pathway
cellular response to hepatocyte growth factor stimulus
regulation of innate immune response
regulation of glucose import
positive regulation of glucose import
positive regulation of melanin biosynthetic process
positive regulation of transport
maintenance of synapse structure
positive regulation of cytokine production involved in inflammatory response
regulation of protein localization to plasma membrane
positive regulation of macropinocytosis
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of G1/S transition of mitotic cell cycle
cell proliferation
regulation of establishment of protein localization to plasma membrane
cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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