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Abnova
APPL2 Polyclonal Antibody, MaxPab™
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Product Details
H00055198-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APPL2 (AAH33731.1, 1 a.a. approximately 664 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPAVDKLLLE EALQDSPQTR SLLSVFEEDA GTLTDYTNQL LQAMQRVYGA QNEMCLATQQ LSKQLLAYEK QNFALGKGDE EVISTLHYFS KVVDELNLLH TELAKQLADT MVLPIIQFRE KDLTEVSTLK DLFGLASNEH DLSMAKYSRL PKKKENEKVK TEVGKEVAAA RRKQHLSSLQ YYCALNALQY RKQMAMMEPM IGFAHGQINF FKKGAEMFSK RMDSFLSSVA DMVQSIQVEL EAEAEKMRVS QQELLSVDES VYTPDSDVAA PQINRNLIQK AGYLNLRNKT GLVTTTWERL YFFTQGGNLM CQPRGAVAGG LIQDLDNCSV MAVDCEDRRY CFQITTPNGK SGIILQAESR KENEEWICAI NNISRQIYLT DNPEAVAIKL NQTALQAVTP ITSFGKKQES SCPSQNLKNS EMENENDKIV PKVTASLPEA EELIAPGTPI QFDIVLPATE FLDQNRGSRR TNPFGETEDE SFPEAEDSLL QQMFIVRFLG SMAVKTDSTT EVIYEAMRQV LAARAIHNIF RMTESHLMVT SQSLRLIDPQ TQVSRANFEL TSVTQFAAHQ ENKRLVGFVI RVPESTGEES LSTYIFESNS EGEKICYAIN LGKEIIEVQK DPEALAQLML SIPLTNDGKY VLLNDQPDDD DGNPNEHRGA ESEA
Target Information
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13 beta; Dip13-beta; unnamed protein product
Gene Aliases: APPL2; DIP13B; RGD1563028
UniProt ID: (Human) Q8NEU8, (Rat) B4F779
Entrez Gene ID: (Human) 55198, (Rat) 362860
diet induced thermogenesis
protein import into nucleus
signal transduction
transforming growth factor beta receptor signaling pathway
cold acclimation
regulation of fibroblast migration
signaling
adiponectin-activated signaling pathway
regulation of toll-like receptor 4 signaling pathway
cellular response to hepatocyte growth factor stimulus
homeostatic process
glucose homeostasis
regulation of innate immune response
negative regulation of fatty acid oxidation
negative regulation of glucose import
negative regulation of neurogenesis
protein homotetramerization
positive regulation of phagocytosis, engulfment
positive regulation of cold-induced thermogenesis
negative regulation of cytokine production involved in inflammatory response
negative regulation of cellular response to insulin stimulus
positive regulation of macropinocytosis
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of G1/S transition of mitotic cell cycle
negative regulation of neural precursor cell proliferation
cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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