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APRIL Polyclonal Antibody
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FIGURE: 1 / 1
APRIL Antibody (600-401-Y53) in WB
Western Blot of APRIL antibody. Lane 1: K562 cells with APRIL at 5 µg/mL. Lane 2: K562 cells with APRIL at 10 µg/mL. Load: 35 µg per lane. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 27.4 kDa, 26 kDa for APRIL. Other band(s): APRIL splice variants and isoforms.
Product Details
600-401-Y53
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-APRIL antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the internal region of human APRIL.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A proliferation-inducing ligand; APRIL; APRIL delta; APRIL epsilon; CD256; ligand; TALL-2; TNF ligand superfamily, member 13; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNFSF13; TRDL-1; TRDL-1alpha; tumor necrosis factor-like ligand; TRDL-1beta; tumor necrosis factor-like ligand; TRDL-1gamma; tumor necrosis factor-like ligand; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7B; Tumor necrosis factor ligand superfamily member 13; tumor necrosis factor superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; unnamed protein product
Gene Aliases: APRIL; CD256; TALL-2; TALL2; TNFSF13; TNLG7B; TRDL-1; UNQ383/PRO715; ZTNF2
UniProt ID: (Human) O75888
Entrez Gene ID: (Human) 8741
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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