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APS Polyclonal Antibody
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Product Details
BS-2731R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human APS, amino acids 401-500.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
APS (adapter protein with Pleckstrin homology and Src homology 2 domains) a member of the Lnk family, is an adaptor protein that is involved in B-cell signaling, insulin signaling, cytoskeletal reorganization. It is tyrosine phosphorylated by JAK2, KIT and other kinases during B-cell receptor stimulation of many different cytokines, chemokines and leukokines. APS has been shown to inhibit the JAK-STAT pathway in collaboration with c-Cbl. It is located in the cytoplasm in pre-PDGF (platelet derived growth factor) stimulated cells and localizes to the plasma membrane and peripheral regions upon PDGF stimulation. This protein is expressed in B-cells and mast cells when detected in haematopoietic cell lines yet is also expressed in many different tissues including spleen, prostrate, testis, uterus, small intestine and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Alpha-1-antitrypsin; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2
Gene Aliases: APS; SH2B2
UniProt ID: (Human) O14492, (Mouse) Q9JID9, (Rat) Q9Z200
Entrez Gene ID: (Human) 10603, (Mouse) 23921, (Rat) 114203
B-1 B cell homeostasis
signal transduction
insulin receptor signaling pathway
cytokine-mediated signaling pathway
regulation of metabolic process
actin cytoskeleton organization
intracellular signal transduction
regulation of immune response
antigen receptor-mediated signaling pathway
B cell receptor signaling pathway
brown fat cell differentiation
nervous system development
positive regulation of signal transduction
regulation of JAK-STAT cascade
regulation of Ras protein signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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