Proteintech

APTX Polyclonal Antibody

View all (10) Aprataxin antibodies

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APTX Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( 4% PFA) fixed HepG2 cells using 26747-1-AP (APTX antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

APTX Antibody in Western Blot (WB) — HEK-293T cells were subjected to SDS PAGE followed by western blot with 26747-1-AP ( APTX Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

26747-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunocytochemistry (ICC/IF)	1:50-1:500	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	APTX Fusion Protein Ag24945 (1-164 aa encoded by BC104881) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.33 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MMRVCWLVR QDSRHQRIRL PHLEAVVIGR GPETKITDKK CSRQQVQLKA ECNKGYVKVK QVGVNPTSID SVVIGKDQEV KLQPGQVLHM VNELYPYIVE FEEEAKNPGL ETHRKRKRSG NSDSIERDAA QEAEAGTGLE PGSNSGQCSV PLKKGKDAPI KKESL (1-164 aa encoded by BC104881)

Target Information

This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Aprataxin; FHA-HIT; Forkhead-associated domain histidine triad-like protein

Gene Aliases: AOA; AOA1; APTX; AXA1; EAOH; EOAHA; FHA-HIT

UniProt ID: (Human) Q7Z2E3

Entrez Gene ID: (Human) 54840

Molecular Function: damaged DNA-binding protein

Function(s)

single strand break repair DNA ligation cellular response to DNA damage stimulus dephosphorylation regulation of protein stability response to hydrogen peroxide nucleic acid phosphodiester bond hydrolysis

Process(es)

chromatin binding damaged DNA binding double-stranded DNA binding double-stranded RNA binding protein binding phosphoglycolate phosphatase activity DNA 5'-adenosine monophosphate hydrolase activity metal ion binding protein N-terminus binding phosphoprotein binding

APTX Polyclonal Antibody

Product Details

26747-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

References (0)

Bioinformatics

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