|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (78 ANVHKTKKNDDPSKDY 93) of ARAP2 protein.|
|Storage buffer||whole serum with 50% glycerol|
|Contains||0.025% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
ARAP2, also known as Centaurin-delta-1, is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein, ARAP2 binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ANK repeat and PH domain-containing protein 2; Arf and Rho GAP adapter protein 2; arf-GAP with Rho-GAP domain; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; centaurin; centaurin, delta 1; Centaurin-delta-1; CENTD1; Cnt-d1; delta 1; PARX; Protein PARX
Gene Aliases: ARAP2; CENTD1; KIAA0580; PARX
UniProt ID: (Human) Q8WZ64
Entrez Gene ID: (Human) 116984
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