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Invitrogen

ARC Polyclonal Antibody

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View all (21) ARC antibodies

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ARC Polyclonal Antibody

Product Details

PA1-16860

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:2,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to residues 125-141 of the human Nop30 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2298470

Product Specific Information

Suggested positive control: antigen standard for NOL3 (transient overexpression lysate).

Immunogen sequence: PELQTLTRPG ALRAPRR

Target Information

ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. ARC inhibits extrinsic apoptotic pathways two different ways. The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation. ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX. This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors. Mutations affecting the gene can results in myoclonus, familiam cortical.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Apoptosis repressor with CARD; muscle specific protein; Muscle-enriched cytoplasmic protein; Myp; Nop 30; Nop30; Nucleolar protein 3; nucleolar protein 3 (apoptosis repressor with CARD domain); Nucleolar protein of 30 kDa; unnamed protein product

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Gene Aliases: ARC; FCM; MYOCL1; MYP; NOL3; NOP; NOP30

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UniProt ID: (Human) O60936

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Entrez Gene ID: (Human) 8996

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Function(s)
RNA binding receptor binding death receptor binding calcium ion binding protein binding death effector domain binding identical protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process metal ion binding caspase binding
Process(es)
response to hypoxia blood vessel remodeling response to ischemia mRNA splice site selection mRNA processing apoptotic process RNA splicing negative regulation of signal transduction regulation of gene expression cardiac muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process negative regulation of cardiac muscle cell apoptotic process negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of muscle atrophy release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to injury involved in regulation of muscle adaptation regulation of apoptotic process negative regulation of apoptotic process protein oligomerization negative regulation of programmed necrotic cell death negative regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway regulation of NIK/NF-kappaB signaling negative regulation of mitochondrial membrane permeability involved in apoptotic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of intracellular signal transduction negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway
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