|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 2-18 of ARC|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-30682 detects ARC from human, mouse, rat samples.
PA1-30682 has been successfully used in Western blot applications.
The PA1-30682 immunogen is Synthetic peptide corresponding to amino acids 2-18 of ARC
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICKBCL10, Apaf-1, caspase-9, and caspase-2. a novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzyamtic activity of capase-8. ARC supresses apoptosis induced by cell death adaptors FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. the messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.