ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008].
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Protein Aliases: ADP-ribosylation factor guanine nucleotide-exchange factor 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Arfgep2; Big2; Brefeldin A-inhibited GEP 2; Brefeldin A-inhibited guanine nucleotide-exchange factor 2; Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Gene Aliases: AI463430; ARFGEF2; ARFGEP2; AW493672; BIG2; dJ1164I10.1; E230011G24Rik; PVNH2