A suggested positive control is NIH-3T3 cell lysate.
PA5-20893 can be used with blocking peptide PEP-1007.
ARHGAP18 is one member of the human RhoGAP family with approximately 80 RhoGAP proteins known to be encoded in the human genome. Rho proteins belong to the Ras superfamily that is composed of over 50 members divided into six families, including Ras, Sar, Rho, Ran, Rab and Arf. Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. ARHGAP18 is linked to Ras, and thus, to EGFR-mediated proliferation, migration and differentiation. ARHGAP18 is precisely contained within chromosome 6q22-24, which has been shown to be linked to schizophrenia, suggesting that ARHGEP18 may play a role in this condition.
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Protein Aliases: ARHGAP18; MacGAP; Rho GTPase-activating protein 18; Rho-type GTPase-activating protein 18
Gene Aliases: 4833419J07Rik; AI314906; AI843501; ARHGAP18; bA307O14.2; MacGAP; SENEX
Molecular Function: GTPase-activating protein