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ARHGAP24 Polyclonal Antibody
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Product Details
BS-5785R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ARHGAP24, amino acids 501-600.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Down-regulated in nephrectomized rat kidney #2; Filamin-A-associated RhoGAP; FilGAP; p73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho GTPase-activating protein 24; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; unnamed protein product
Gene Aliases: 0610025G21Rik; ARHGAP24; DR-NR#2; FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72
UniProt ID: (Human) Q8N264, (Mouse) Q8C4V1, (Rat) Q5U2Z7
Entrez Gene ID: (Human) 83478, (Mouse) 231532, (Rat) 305156
angiogenesis
signal transduction
multicellular organism development
cell differentiation
negative regulation of Rac protein signal transduction
wound healing, spreading of epidermal cells
activation of GTPase activity
negative regulation of ruffle assembly
regulation of small GTPase mediated signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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