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Immunogen sequence: VALQGRVNQ LVQTLIVQPD RVFPPLTSLP GPVYEKCMAP PSASCLGDAQ LESLGADNEP ELEAEMPAQE DDLEGVVEAV ACFAYTGRTA QELSFRRGDV LRLHERASSD WWRGEHNGMR GLIPHKYITL PAGTEKQVVG AGLQTAGESG SSPEGLLASE LVHRPEPCTS PEAMGPSGHR RRCLVPASPE QHVEVDKAVA QNMDSVFKEL LGKTSVRQGL GPASTTSPSP GPRSPKAPPS SRLGRNKGFS RGPGAPASPS ASHPQGLDTT PKPH (714-986 aa encoded by B C052303)
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: p115; RG RhoGAP4; Rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4
Gene Aliases: ARHGAP4; C1; KIAA0131; p115; RGC1; RHOGAP4; SrGAP4
UniProt ID: (Human) P98171
Entrez Gene ID: (Human) 393
Molecular Function: GTPase-activating protein