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Proteintech
ARHGAP44 Polyclonal Antibody
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Product Details
32382-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARHGAP44 fusion protein Ag38196
Conjugate
Form
Liquid
Concentration
400 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: LQPGPERTST TKSKELSPGS AQKGSPGSSQ GTACAGTQPG AQPGAQPGAS PSPSQPPADQ SPHTLRKVSK KLAPIPPKVP FGQPGAMADQ SAGQPSPVSL SPTPPSTPSP YGLSYPQGYS LASGQLSPAA APPLASPSVF TSTLSKSRPT PKPRQRPTLP PPQPPTVNLS ASSPQSTEAP MLDGMSPGES MST
Target Information
GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NPC-A-10; Rho GTPase-activating protein 44; rho GTPase-activating protein RICH2; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; RICH-2
Gene Aliases: ARHGAP44; KIAA0672; NPC-A-10; RICH2
UniProt ID: (Human) Q17R89
Entrez Gene ID: (Human) 9912
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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