Sequence of this protein is as follows: MTEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK TLLGDGPVVT DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV LKEGSEYRVK IHFKVNRDIV SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP EEYEFLTPVE EAPKGMLARG TYHNKSFFTD DDKQDHLSWE WNLSIKKEWT E
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
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Protein Aliases: D4; d4 gdi; GDI LYGDI; Ly-GDI; Rho GDI 2; Rho GDP dissociation inhibitor (GDI) beta; Rho GDP-dissociation inhibitor 2; Rho-GDI beta
Gene Aliases: ARHGDIB; D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1; RhoGDI2