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Immunogen sequence: MEDFARGAA SPGPSRPGLV PVSIIGAEDE DFENELETNS EEQNSQFQSL EQVKRRPAHL MALLQHVALQ FEPGPLVLRV PVPPNVAFEL DRTRADLISE DVQRRFVQEV VQSQQVAVGR QLEDFRSKRL MGMTPWEQEL AQLEAWVGRD RASYEARERH VAERLLMHLE EMQHTISTDE EKSAAVVNAI GLYMRHLGVR TKSGDKKSGR NFFRKKVMGN RRSDEPAKTK KGLSSILDAA RWNRGEPQVP DFRHLKAEVD AEKPGATDRK GGVGMPSRDR NIGAPGQDTP GVSLHPLSLD SPDREPGADA PLELGDSSPQ GPMSLESLAP PESTDEGAET ESPEPGDEGE P (1-350 aa encoded by BC011726)
The Ras superfamily of GTPases, which can be subdivided into the Ras, Rho/Rac, Sar, Rab, ARF and Ran subfamilies, controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. The Ras superfamily of GTPases function as regulated switches that toggle between a biologically active GTP-bound and an inactive GDP-bound form. This activation is catalyzed by guanine nucleotide exchange factors (GEFs). The Dbl-related proteins are a large family of structurally related molecules that have a common ability to catalyze GEF activity for specific members of the Ras family. Dbl-related proteins include FGD1, Lsc, RhoGEF p115, Lfc, Lbc and Brx. Lsc, Lbc and Lfc share sequence homology and show exchange activity toward Rho family GTPases. RhoGEF p115 catalyzes GEF activity for Rho but not Rac, Cdc42 or Ras GTPases.
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Protein Aliases: 115 kDa guanine nucleotide exchange factor; 115-kD protein; Lbc's second cousin; Lsc homolog; lymphoid blast crisis like 2; Lymphoid blast crisis-like 2; p115-RhoGEF; p115RhoGEF; Rho guanine nucleotide exchange factor (GEF) 1; Rho guanine nucleotide exchange factor 1; Sub1.5
Gene Aliases: ARHGEF1; GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5
Molecular Function: guanyl-nucleotide exchange factor