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Invitrogen
ARHGEF5 Polyclonal Antibody
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FIGURE: 1 / 2
ARHGEF5 Antibody (PA5-114877) in ICC/IF
Immunocytochemistry analysis of ARHGEF5 in 3T3 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114877) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Product Details
PA5-114877
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ARHGEF5(Accession Q12774), corresponding to amino acid residues V985-W1035.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ARHGEF5.
Target Information
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARH5; DKFZp686N1969; Ephexin 3; Ephexin-3; ephexin3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; p60 TIM; Rho guanine nucleotide exchange factor (GEF) 5; Rho guanine nucleotide exchange factor 5; Transforming immortalized mammary oncogene; unnamed protein product
Gene Aliases: 2210412D05Rik; AA717842; ARHGEF5; AW495314; GEF5; P60; TIM; TIM1
UniProt ID: (Human) Q12774, (Mouse) E9Q7D5
Entrez Gene ID: (Human) 7984, (Mouse) 54324, (Rat) 140898
myeloid dendritic cell chemotaxis
actin cytoskeleton organization
regulation of actin cytoskeleton organization
intracellular signal transduction
regulation of GTPase activity
positive regulation of JUN kinase activity
regulation of small GTPase mediated signal transduction
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of cytoskeleton organization
positive regulation of stress fiber assembly
hematopoietic stem cell homeostasis
regulation of ERK1 and ERK2 cascade
positive regulation of podosome assembly
positive regulation of protein import
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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