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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 239 and 489 of Human ARHGEF7|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27508 targets ARHGEF7 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27508 immunogen is recombinant fragment corresponding to a region within amino acids 239 and 489 of Human ARHGEF7.
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BETA-PIX; COOL1; guanine nucleotide exchange factor 7; Nbla10314; P50; P50BP; P85COOL1; P85SPR; PAK-interacting exchange factor beta; PAK3; PIXB; Rho guanine nucleotide exchange factor (GEF) 7; rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
ARHGEF7; BETA-PIX; COOL-1; COOL1; KIAA0142; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PAK3BP; PIXB