Positive Control: HeLa, HeLa nuclear extract
Predicted Reactivity: Mouse (81%), Rat (80%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ARID5B encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. ARID5B also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein Aliases: ARID domain-containing protein 5B; AT rich interactive domain 5B (MRF1-like); AT-rich interactive domain 5B (MRF1-like); AT-rich interactive domain-containing protein 5B; Modulator recognition factor 2; modulator recognition factor 2 (MRF2); MRF-2; MRF1-like protein
Gene Aliases: ARID5B; DESRT; MRF-2; MRF2
UniProt ID: (Human) Q14865
Entrez Gene ID: (Human) 84159
Molecular Function: transcription cofactor