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Proteintech
ARIH1 Polyclonal Antibody
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Product Details
14949-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARIH1 fusion protein Ag6760
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
90 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MQCWSEYLTT KIMEEGMGQT ISCPAHGCDI LVDDNTVMRL ITDSKVKLKY QHLITNSFVE CNRLLKWCPA PDCHHVVKVQ YPDAKPVRCK CGRQFCFNCG ENWHDPVKCK WLKKWIKKCD DDSETSNWIA ANTKECPKCH VTIEKDGGCN HMVCRNQNCK AEFCWVCLGP WEPHGSAWYN CNRYNEDDAK AARDAQERSR AALQRYLFYC NRYMNHMQSL RFEHKLYAQV KQKMEEMQQH NMSWIEVQFL KKAVDVLCQC RATLMYTYVF AFYLKKNNQS IIFENNQADL ENATEVLSG
Target Information
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916). In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ARI-1; ARI; E3; ariadne 1; ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1; ariadne, Drosophila, homolog of; DKFZp686O13120; E3 ubiquitin-protein ligase ARIH1; FLJ20329; FLJ93118; H7-AP2; HHARI; Monocyte protein 6; MOP-6; Protein ariadne-1 homolog; UbcH7-binding protein; UbcM4-interacting protein; UbcM4-interacting protein 77; Ubiquitin-conjugating enzyme E2-binding protein 1; unnamed protein product
Gene Aliases: ARI; Ari1; ARIH1; AU021774; HARI; HHARI; HUSSY-27; MOP6; UBCH7BP; Uip77
UniProt ID: (Human) Q9Y4X5, (Mouse) Q9Z1K5
Entrez Gene ID: (Human) 25820, (Mouse) 23806
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ubiquitin-like protein transferase activity
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
metal ion binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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