This antibody is predicted to react with rat based on sequence homology.
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
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Protein Aliases: AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; ARK5; KIAA0537; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; NUAK1; Omphalocele kinase 1
Gene Aliases: ARK5; KIAA0537; NUAK1; OMPHK1
UniProt ID: (Human) O60285
Entrez Gene ID: (Human) 9891