Product References
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.
Cilia
Hoang-Minh LB,Dutra-Clarke M,Breunig JJ,Sarkisian MR
Fri Apr 08 00:00:00 EDT 2022
Abnormal glycosylation in Joubert syndrome type 10.
Cilia
Kane MS,Davids M,Bond MR,Adams CJ,Grout ME,Phelps IG,O'Day DR,Dempsey JC,Li X,Golas G,Vezina G,Gunay-Aygun M,Hanover JA,Doherty D,He M,Malicdan MCV,Gahl WA,Boerkoel CF
Thu Oct 01 00:00:00 EDT 2020
Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.
Cilia
Duran I,Taylor SP,Zhang W,Martin J,Qureshi F,Jacques SM,Wallerstein R,Lachman RS,Nickerson DA,Bamshad M,Cohn DH,Krakow D
Wed Sep 30 00:00:00 EDT 2020
Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation.
Molecular vision
Chen HY,Kaya KD,Dong L,Swaroop A
Fri Mar 06 00:00:00 EST 2020
Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.
Autophagy
Liu ZQ,Lee JN,Son M,Lim JY,Dutta RK,Maharjan Y,Kwak S,Oh GT,Byun K,Choe SK,Park R
Wed Oct 02 00:00:00 EDT 2019
Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued.
Journal of cellular physiology
Chen TY,Lien WC,Cheng HL,Kuan TS,Sheu SY,Wang CY
Mon Jul 01 00:00:00 EDT 2019
Tubular flow activates magnesium transport in the distal convoluted tubule.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Verschuren EHJ,Hoenderop JGJ,Peters DJM,Arjona FJ,Bindels RJM
Mon Apr 01 00:00:00 EDT 2019
Indian Hedgehog links obesity to development of hepatocellular carcinoma.
Oncogene
Chong YC,Lim TE,Fu Y,Shin EM,Tergaonkar V,Han W
Fri Mar 01 00:00:00 EST 2019
The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling.
Human molecular genetics
Massa F,Tammaro R,Prado MA,Cesana M,Lee BH,Finley D,Franco B,Morleo M
Fri Mar 01 00:00:00 EST 2019
Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.
Cellular and molecular life sciences : CMLS
Patnaik SR,Kretschmer V,Brücker L,Schneider S,Volz AK,Oancea-Castillo LDR,May-Simera HL
Fri Feb 01 00:00:00 EST 2019
Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl-]i in mouse airway cilia.
Pflugers Archiv : European journal of physiology
Ikeuchi Y,Kogiso H,Hosogi S,Tanaka S,Shimamoto C,Matsumura H,Inui T,Marunaka Y,Nakahari T
Fri Feb 01 00:00:00 EST 2019
Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.
The EMBO journal
Singer D,Thamm K,Zhuang H,Karbanová J,Gao Y,Walker JV,Jin H,Wu X,Coveney CR,Marangoni P,Lu D,Grayson PRC,Gulsen T,Liu KJ,Ardu S,Wann AK,Luo S,Zambon AC,Jetten AM,Tredwin C,Klein OD,Attanasio M,Carmeliet P,Huttner WB,Corbeil D,Hu B
Tue Jan 15 00:00:00 EST 2019
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines.
Development (Cambridge, England)
Capowski EE,Samimi K,Mayerl SJ,Phillips MJ,Pinilla I,Howden SE,Saha J,Jansen AD,Edwards KL,Jager LD,Barlow K,Valiauga R,Erlichman Z,Hagstrom A,Sinha D,Sluch VM,Chamling X,Zack DJ,Skala MC,Gamm DM
Wed Jan 09 00:00:00 EST 2019
Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.
Redox biology
Kong MJ,Bak SH,Han KH,Kim JI,Park JW,Park KM
Tue Jan 01 00:00:00 EST 2019
Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.
Redox biology
Kong MJ,Bak SH,Han KH,Kim JI,Park JW,Park KM
Tue Jan 01 00:00:00 EST 2019
Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.
Nature communications
Vuong LT,Iomini C,Balmer S,Esposito D,Aaronson SA,Mlodzik M
Thu Dec 13 00:00:00 EST 2018
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
Journal of cell science
Nagai T,Mukoyama S,Kagiwada H,Goshima N,Mizuno K
Wed Dec 12 00:00:00 EST 2018
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Nature communications
Tu HQ,Qin XH,Liu ZB,Song ZQ,Hu HB,Zhang YC,Chang Y,Wu M,Huang Y,Bai YF,Wang G,Han QY,Li AL,Zhou T,Liu F,Zhang XM,Li HY
Tue Dec 11 00:00:00 EST 2018
Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.
Proceedings of the National Academy of Sciences of the United States of America
Ramsbottom SA,Molinari E,Srivastava S,Silberman F,Henry C,Alkanderi S,Devlin LA,White K,Steel DH,Saunier S,Miles CG,Sayer JA
Tue Dec 04 00:00:00 EST 2018
Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.
Proceedings of the National Academy of Sciences of the United States of America
Ramsbottom SA,Molinari E,Srivastava S,Silberman F,Henry C,Alkanderi S,Devlin LA,White K,Steel DH,Saunier S,Miles CG,Sayer JA
Tue Dec 04 00:00:00 EST 2018
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
Developmental cell
Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL
Mon Nov 19 00:00:00 EST 2018
Membrane association and remodeling by intraflagellar transport protein IFT172.
Nature communications
Wang Q,Taschner M,Ganzinger KA,Kelley C,Villasenor A,Heymann M,Schwille P,Lorentzen E,Mizuno N
Thu Nov 08 00:00:00 EST 2018
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
eLife
Vuolo L,Stevenson NL,Heesom KJ,Stephens DJ
Tue Oct 16 00:00:00 EDT 2018
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.
Nature communications
Buskin A,Zhu L,Chichagova V,Basu B,Mozaffari-Jovin S,Dolan D,Droop A,Collin J,Bronstein R,Mehrotra S,Farkas M,Hilgen G,White K,Pan KT,Treumann A,Hallam D,Bialas K,Chung G,Mellough C,Ding Y,Krasnogor N,Przyborski S,Zwolinski S,Al-Aama J,Alharthi S,Xu Y,Wheway G,Szymanska K,McKibbin M,Inglehearn CF,Elliott DJ,Lindsay S,Ali RR,Steel DH,Armstrong L,Sernagor E,Urlaub H,Pierce E,Lührmann R,Grellscheid SN,Johnson CA,Lako M
Fri Oct 12 00:00:00 EDT 2018
The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Developmental cell
Stephen LA,ElMaghloob Y,McIlwraith MJ,Yelland T,Castro Sanchez P,Roda-Navarro P,Ismail S
Mon Oct 08 00:00:00 EDT 2018
ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.
American journal of human genetics
Alkanderi S,Molinari E,Shaheen R,Elmaghloob Y,Stephen LA,Sammut V,Ramsbottom SA,Srivastava S,Cairns G,Edwards N,Rice SJ,Ewida N,Alhashem A,White K,Miles CG,Steel DH,Alkuraya FS,Ismail S,Sayer JA
Thu Oct 04 00:00:00 EDT 2018
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Abdelhamed ZA,Ryan TA,Fuller M,Coulson-Gilmer C,Abdelmottaleb DI,Wang TL,Kaun JC,Wang P,Hutson R,Wilkinson N,Bell SM,Johnson CA
Mon Oct 01 00:00:00 EDT 2018
Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa.
Journal of medical genetics
de Bruijn SE,Verbakel SK,de Vrieze E,Kremer H,Cremers FPM,Hoyng CB,van den Born LI,Roosing S
Mon Oct 01 00:00:00 EDT 2018
A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy.
Nature
Sánchez-Danés A,Larsimont JC,Liagre M,Muñoz-Couselo E,Lapouge G,Brisebarre A,Dubois C,Suppa M,Sukumaran V,Del Marmol V,Tabernero J,Blanpain C
Mon Oct 01 00:00:00 EDT 2018
A distal centriolar protein network controls organelle maturation and asymmetry.
Nature communications
Wang L,Failler M,Fu W,Dynlacht BD
Wed Sep 26 00:00:00 EDT 2018
A distal centriolar protein network controls organelle maturation and asymmetry.
Nature communications
Wang L,Failler M,Fu W,Dynlacht BD
Wed Sep 26 00:00:00 EDT 2018
LRRC45 contributes to early steps of axoneme extension.
Journal of cell science
Kurtulmus B,Yuan C,Schuy J,Neuner A,Hata S,Kalamakis G,Martin-Villalba A,Pereira G
Thu Sep 20 00:00:00 EDT 2018
LRRC45 contributes to early steps of axoneme extension.
Journal of cell science
Kurtulmus B,Yuan C,Schuy J,Neuner A,Hata S,Kalamakis G,Martin-Villalba A,Pereira G
Thu Sep 20 00:00:00 EDT 2018
Dorsoventral differences in cAMP levels and correlated changes in the subcellular distribution of the PKA catalytic domain, provide further evidence that PKA signaling coordinates dorsoventral patterning of the otocyst.
Development, growth & differentiation
Ohta S,Schoenwolf GC
Sat Sep 01 00:00:00 EDT 2018
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
Nature communications
He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J
Fri Aug 17 00:00:00 EDT 2018
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
Nature communications
He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J
Fri Aug 17 00:00:00 EDT 2018
Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.
Human molecular genetics
Barny I,Perrault I,Michel C,Soussan M,Goudin N,Rio M,Thomas S,Attié-Bitach T,Hamel C,Dollfus H,Kaplan J,Rozet JM,Gerard X
Wed Aug 01 00:00:00 EDT 2018
Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.
Oncogene
Lee J,Yi S,Won M,Song YS,Yi HS,Park YJ,Park KC,Kim JT,Chang JY,Lee MJ,Sul HJ,Choi JE,Kim KS,Kero J,Kim J,Shong M
Wed Aug 01 00:00:00 EDT 2018
Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.
Neuron
Park SM,Lim JS,Ramakrishina S,Kim SH,Kim WK,Lee J,Kang HC,Reiter JF,Kim DS,Kim HH,Lee JH
Wed Jul 11 00:00:00 EDT 2018
EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
Cancer cell
Zingg D,Debbache J,Peña-Hernández R,Antunes AT,Schaefer SM,Cheng PF,Zimmerli D,Haeusel J,Calçada RR,Tuncer E,Zhang Y,Bossart R,Wong KK,Basler K,Dummer R,Santoro R,Levesque MP,Sommer L
Mon Jul 09 00:00:00 EDT 2018
EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
Cancer cell
Zingg D,Debbache J,Peña-Hernández R,Antunes AT,Schaefer SM,Cheng PF,Zimmerli D,Haeusel J,Calçada RR,Tuncer E,Zhang Y,Bossart R,Wong KK,Basler K,Dummer R,Santoro R,Levesque MP,Sommer L
Mon Jul 09 00:00:00 EDT 2018
CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.
Molecular & cellular proteomics : MCP
Beyer T,Bolz S,Junger K,Horn N,Moniruzzaman M,Wissinger Y,Ueffing M,Boldt K
Sun Jul 01 00:00:00 EDT 2018
Primary cilia-regulated transcriptome in the renal collecting duct.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mohammed SG,Arjona FJ,Verschuren EHJ,Bakey Z,Alkema W,van Hijum S,Schmidts M,Bindels RJM,Hoenderop JGJ
Sun Jul 01 00:00:00 EDT 2018
Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.
Experimental & molecular medicine
Dafinger C,Rinschen MM,Borgal L,Ehrenberg C,Basten SG,Franke M,Höhne M,Rauh M,Göbel H,Bloch W,Wunderlich FT,Peters DJM,Tasche D,Mishra T,Habbig S,Dötsch J,Müller RU,Brüning JC,Persigehl T,Giles RH,Benzing T,Schermer B,Liebau MC
Thu Jun 28 00:00:00 EDT 2018
Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Coveney CR,Collins I,Mc Fie M,Chanalaris A,Yamamoto K,Wann AKT
Tue Jun 19 00:00:00 EDT 2018
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
Cell reports
Jenks AD,Vyse S,Wong JP,Kostaras E,Keller D,Burgoyne T,Shoemark A,Tsalikis A,de la Roche M,Michaelis M,Cinatl J,Huang PH,Tanos BE
Tue Jun 05 00:00:00 EDT 2018
Autophagy alteration prevents primary cilium disassembly in RPE1 cells.
Biochemical and biophysical research communications
Maharjan Y,Lee JN,Kwak S,Lim H,Dutta RK,Liu ZQ,So HS,Park R
Sat Jun 02 00:00:00 EDT 2018
Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.
The American journal of pathology
Shannon ML,Fame RM,Chau KF,Dani N,Calicchio ML,Géléoc GS,Lidov HGW,Alexandrescu S,Lehtinen MK
Fri Jun 01 00:00:00 EDT 2018
Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.
The American journal of pathology
Shannon ML,Fame RM,Chau KF,Dani N,Calicchio ML,Géléoc GS,Lidov HGW,Alexandrescu S,Lehtinen MK
Fri Jun 01 00:00:00 EDT 2018
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
The EMBO journal
Wiegering A,Dildrop R,Kalfhues L,Spychala A,Kuschel S,Lier JM,Zobel T,Dahmen S,Leu T,Struchtrup A,Legendre F,Vesque C,Schneider-Maunoury S,Saunier S,Rüther U,Gerhardt C
Tue May 15 00:00:00 EDT 2018
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
The Journal of cell biology
Vion AC,Alt S,Klaus-Bergmann A,Szymborska A,Zheng T,Perovic T,Hammoutene A,Oliveira MB,Bartels-Klein E,Hollfinger I,Rautou PE,Bernabeu MO,Gerhardt H
Mon May 07 00:00:00 EDT 2018
Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.
Journal of cell science
Stevenson NL,Bergen DJM,Xu A,Wyatt E,Henry F,McCaughey J,Vuolo L,Hammond CL,Stephens DJ
Fri May 04 00:00:00 EDT 2018
The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.
Journal of cell science
Revenkova E,Liu Q,Gusella GL,Iomini C
Fri May 04 00:00:00 EDT 2018
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
EMBO reports
Jeong AL,Ka HI,Han S,Lee S,Lee EW,Soh SJ,Joo HJ,Sumiyasuren B,Park JY,Lim JS,Park JH,Lee MS,Yang Y
Tue May 01 00:00:00 EDT 2018
Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice.
Cell death & disease
Wang B,Zhang Y,Dong H,Gong S,Wei B,Luo M,Wang H,Wu X,Liu W,Xu X,Zheng Y,Sun M
Tue May 01 00:00:00 EDT 2018
Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.
Biology open
Takei R,Katoh Y,Nakayama K
Mon Apr 30 00:00:00 EDT 2018
Centrobin controls primary ciliogenesis in vertebrates.
The Journal of cell biology
Ogungbenro YA,Tena TC,Gaboriau D,Lalor P,Dockery P,Philipp M,Morrison CG
Mon Apr 02 00:00:00 EDT 2018
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size.
Nature
Johnson MB,Sun X,Kodani A,Borges-Monroy R,Girskis KM,Ryu SC,Wang PP,Patel K,Gonzalez DM,Woo YM,Yan Z,Liang B,Smith RS,Chatterjee M,Coman D,Papademetris X,Staib LH,Hyder F,Mandeville JB,Grant PE,Im K,Kwak H,Engelhardt JF,Walsh CA,Bae BI
Sun Apr 01 00:00:00 EDT 2018
Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.
Neuron
Tavano S,Taverna E,Kalebic N,Haffner C,Namba T,Dahl A,Wilsch-Bräuninger M,Paridaen JTML,Huttner WB
Wed Mar 21 00:00:00 EDT 2018
Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.
Human molecular genetics
Kunova Bosakova M,Varecha M,Hampl M,Duran I,Nita A,Buchtova M,Dosedelova H,Machat R,Xie Y,Ni Z,Martin JH,Chen L,Jansen G,Krakow D,Krejci P
Thu Mar 15 00:00:00 EDT 2018
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.
The Journal of cell biology
Fernández-Barrera J,Bernabé-Rubio M,Casares-Arias J,Rangel L,Fernández-Martín L,Correas I,Alonso MA
Mon Mar 05 00:00:00 EST 2018
Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain.
Journal of molecular neuroscience : MN
Sipos É,Komoly S,Ács P
Thu Mar 01 00:00:00 EST 2018
Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition.
Biochemical and biophysical research communications
Han SJ,Jung JK,Im SS,Lee SR,Jang BC,Park KM,Kim JI
Mon Feb 05 00:00:00 EST 2018
DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.
Human molecular genetics
Hartill VL,van de Hoek G,Patel MP,Little R,Watson CM,Berry IR,Shoemark A,Abdelmottaleb D,Parkes E,Bacchelli C,Szymanska K,Knoers NV,Scambler PJ,Ueffing M,Boldt K,Yates R,Winyard PJ,Adler B,Moya E,Hattingh L,Shenoy A,Hogg C,Sheridan E,Roepman R,Norris D,Mitchison HM,Giles RH,Johnson CA
Thu Feb 01 00:00:00 EST 2018
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Kidney international
Wang Q,Cobo-Stark P,Patel V,Somlo S,Han PL,Igarashi P
Thu Feb 01 00:00:00 EST 2018
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lee SH,Joo K,Jung EJ,Hong H,Seo J,Kim J
Thu Feb 01 00:00:00 EST 2018
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
EMBO reports
Kim YJ,Osborn DP,Lee JY,Araki M,Araki K,Mohun T,Känsäkoski J,Brandstack N,Kim HT,Miralles F,Kim CH,Brown NA,Kim HG,Martinez-Barbera JP,Ataliotis P,Raivio T,Layman LC,Kim SH
Thu Feb 01 00:00:00 EST 2018
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
American journal of human genetics
Bozal-Basterra L,Martín-Ruíz I,Pirone L,Liang Y,Sigurðsson JO,Gonzalez-Santamarta M,Giordano I,Gabicagogeascoa E,de Luca A,Rodríguez JA,Wilkie AOM,Kohlhase J,Eastwood D,Yale C,Olsen JV,Rauchman M,Anderson KV,Sutherland JD,Barrio R
Thu Feb 01 00:00:00 EST 2018
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Cell reports
Canning P,Park K,Gonçalves J,Li C,Howard CJ,Sharpe TD,Holt LJ,Pelletier L,Bullock AN,Leroux MR
Tue Jan 23 00:00:00 EST 2018
Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development.
Human molecular genetics
Broix L,Asselin L,Silva CG,Ivanova EL,Tilly P,Gilet JG,Lebrun N,Jagline H,Muraca G,Saillour Y,Drouot N,Reilly ML,Francis F,Benmerah A,Bahi-Buisson N,Belvindrah R,Nguyen L,Godin JD,Chelly J,Hinckelmann MV
Mon Jan 15 00:00:00 EST 2018
Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.
Human molecular genetics
Ryan R,Failler M,Reilly ML,Garfa-Traore M,Delous M,Filhol E,Reboul T,Bole-Feysot C,Nitschké P,Baudouin V,Amselem S,Escudier E,Legendre M,Benmerah A,Saunier S
Mon Jan 15 00:00:00 EST 2018
Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy.
Methods in molecular biology (Clifton, N.J.)
Ghossoub R,Lindbæk L,Molla-Herman A,Schmitt A,Christensen ST,Benmerah A
Fri Jan 12 00:00:00 EST 2018
Targeting of ASH Domain-Containing Proteins to the Centrosome.
Methods in molecular biology (Clifton, N.J.)
Verdier P,Morthorst SK,Pedersen LB
Fri Jan 12 00:00:00 EST 2018
Methods for Visualization of Neuronal Cilia.
Methods in molecular biology (Clifton, N.J.)
Caspary T,Marazziti D,Berbari NF
Fri Jan 12 00:00:00 EST 2018
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
Journal of cell science
Takahashi K,Nagai T,Chiba S,Nakayama K,Mizuno K
Mon Jan 08 00:00:00 EST 2018
Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.
Cell reports
May-Simera HL,Wan Q,Jha BS,Hartford J,Khristov V,Dejene R,Chang J,Patnaik S,Lu Q,Banerjee P,Silver J,Insinna-Kettenhofen C,Patel D,Lotfi M,Malicdan M,Hotaling N,Maminishkis A,Sridharan R,Brooks B,Miyagishima K,Gunay-Aygun M,Pal R,Westlake C,Miller S,Sharma R,Bharti K
Tue Jan 02 00:00:00 EST 2018
Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Human molecular genetics
Martin L,Kaci N,Estibals V,Goudin N,Garfa-Traore M,Benoist-Lasselin C,Dambroise E,Legeai-Mallet L
Mon Jan 01 00:00:00 EST 2018
Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Human molecular genetics
Martin L,Kaci N,Estibals V,Goudin N,Garfa-Traore M,Benoist-Lasselin C,Dambroise E,Legeai-Mallet L
Mon Jan 01 00:00:00 EST 2018
The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.
The Journal of biological chemistry
Hanke-Gogokhia C,Wu Z,Sharif A,Yazigi H,Frederick JM,Baehr W
Fri Dec 29 00:00:00 EST 2017
The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.
The Journal of biological chemistry
Hanke-Gogokhia C,Wu Z,Sharif A,Yazigi H,Frederick JM,Baehr W
Fri Dec 29 00:00:00 EST 2017
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Developmental cell
Sigg MA,Menchen T,Lee C,Johnson J,Jungnickel MK,Choksi SP,Garcia G,Busengdal H,Dougherty GW,Pennekamp P,Werner C,Rentzsch F,Florman HM,Krogan N,Wallingford JB,Omran H,Reiter JF
Mon Dec 18 00:00:00 EST 2017
Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.
Scientific reports
Bizzotto S,Uzquiano A,Dingli F,Ershov D,Houllier A,Arras G,Richards M,Loew D,Minc N,Croquelois A,Houdusse A,Francis F
Mon Dec 11 00:00:00 EST 2017
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.
Nature communications
Taulet N,Vitre B,Anguille C,Douanier A,Rocancourt M,Taschner M,Lorentzen E,Echard A,Delaval B
Mon Dec 04 00:00:00 EST 2017
An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.
The Journal of cell biology
Taniguchi K,Shao Y,Townshend RF,Cortez CL,Harris CE,Meshinchi S,Kalantry S,Fu J,O'Shea KS,Gumucio DL
Mon Dec 04 00:00:00 EST 2017
Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
Genetics
Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE
Fri Dec 01 00:00:00 EST 2017
A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.
European journal of human genetics : EJHG
Rafiullah R,Long AB,Ivanova AA,Ali H,Berkel S,Mustafa G,Paramasivam N,Schlesner M,Wiemann S,Wade RC,Bolthauser E,Blum M,Kahn RA,Caspary T,Rappold GA
Fri Dec 01 00:00:00 EST 2017
A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.
Human molecular genetics
Srivastava S,Ramsbottom SA,Molinari E,Alkanderi S,Filby A,White K,Henry C,Saunier S,Miles CG,Sayer JA
Fri Dec 01 00:00:00 EST 2017
Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division.
Developmental biology
Schock EN,Brugmann SA
Wed Nov 15 00:00:00 EST 2017
Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.
Stem cells and development
Vestergaard ML,Grubb S,Koefoed K,Anderson-Jenkins Z,Grunnet-Lauridsen K,Calloe K,Clausen C,Christensen ST,Møllgård K,Andersen CY
Wed Nov 01 00:00:00 EDT 2017
A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.
Genesis (New York, N.Y. : 2000)
Schmitz F,Burtscher I,Stauber M,Gossler A,Lickert H
Wed Nov 01 00:00:00 EDT 2017
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.
The Journal of biological chemistry
Roy K,Jerman S,Jozsef L,McNamara T,Onyekaba G,Sun Z,Marin EP
Fri Oct 27 00:00:00 EDT 2017
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.
The Journal of biological chemistry
Roy K,Jerman S,Jozsef L,McNamara T,Onyekaba G,Sun Z,Marin EP
Fri Oct 27 00:00:00 EDT 2017
Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome.
Journal of cell science
Prosseda PP,Luo N,Wang B,Alvarado JA,Hu Y,Sun Y
Sun Oct 15 00:00:00 EDT 2017
Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.
PloS one
Nagai T,Mizuno K
Wed Oct 04 00:00:00 EDT 2017
GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Neurobiology of disease
Giddens MM,Wong JC,Schroeder JP,Farrow EG,Smith BM,Owino S,Soden SE,Meyer RC,Saunders C,LePichon JB,Weinshenker D,Escayg A,Hall RA
Sun Oct 01 00:00:00 EDT 2017
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
European cells & materials
Thompson CL,Plant JC,Wann AK,Bishop CL,Novak P,Mitchison HM,Beales PL,Chapple JP,Knight MM
Wed Sep 20 00:00:00 EDT 2017
Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.
Journal of neuroinflammation
Baek H,Shin HJ,Kim JJ,Shin N,Kim S,Yi MH,Zhang E,Hong J,Kang JW,Kim Y,Kim CS,Kim DW
Tue Sep 19 00:00:00 EDT 2017
Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.
Journal of neuroinflammation
Baek H,Shin HJ,Kim JJ,Shin N,Kim S,Yi MH,Zhang E,Hong J,Kang JW,Kim Y,Kim CS,Kim DW
Tue Sep 19 00:00:00 EDT 2017
CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
American journal of human genetics
Windpassinger C,Piard J,Bonnard C,Alfadhel M,Lim S,Bisteau X,Blouin S,Ali NB,Ng AYJ,Lu H,Tohari S,Talib SZA,van Hul N,Caldez MJ,Van Maldergem L,Yigit G,Kayserili H,Youssef SA,Coppola V,de Bruin A,Tessarollo L,Choi H,Rupp V,Roetzer K,Roschger P,Klaushofer K,Altmüller J,Roy S,Venkatesh B,Ganger R,Grill F,Ben Chehida F,Wollnik B,Altunoglu U,Al Kaissi A,Reversade B,Kaldis P
Thu Sep 07 00:00:00 EDT 2017
The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.
EMBO reports
Kohli P,Höhne M,Jüngst C,Bertsch S,Ebert LK,Schauss AC,Benzing T,Rinschen MM,Schermer B
Fri Sep 01 00:00:00 EDT 2017
Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.
Journal of cellular physiology
Thorpe SD,Gambassi S,Thompson CL,Chandrakumar C,Santucci A,Knight MM
Fri Sep 01 00:00:00 EDT 2017
Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.
Journal of medical genetics
Nguyen TT,Hull S,Roepman R,van den Born LI,Oud MM,de Vrieze E,Hetterschijt L,Letteboer SJF,van Beersum SEC,Blokland EA,Yntema HG,Cremers FPM,van der Zwaag PA,Arno G,van Wijk E,Webster AR,Haer-Wigman L
Fri Sep 01 00:00:00 EDT 2017
Immunofluorescent staining of septins in primary cilia.
Methods in cell biology
Kim MS,Froese CD,Xie H,Trimble WS
Mon Aug 21 00:00:00 EDT 2017
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.
PloS one
Grzelak CA,Sigglekow ND,Tirnitz-Parker JE,Hamson EJ,Warren A,Maneck B,Chen J,Patkunanathan B,Boland J,Cheng R,Shackel NA,Seth D,Bowen DG,Martelotto LG,Watkins DN,McCaughan GW
Wed Aug 09 00:00:00 EDT 2017
Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Toriyama M,Toriyama M,Wallingford JB,Finnell RH
Tue Aug 01 00:00:00 EDT 2017
A novel role for primary cilia in airway remodeling.
American journal of physiology. Lung cellular and molecular physiology
Trempus CS,Song W,Lazrak A,Yu Z,Creighton JR,Young BM,Heise RL,Yu YR,Ingram JL,Tighe RM,Matalon S,Garantziotis S
Tue Aug 01 00:00:00 EDT 2017
Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis.
Cell
Kopinke D,Roberson EC,Reiter JF
Thu Jul 13 00:00:00 EDT 2017
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Cell reports
Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A
Tue Jul 11 00:00:00 EDT 2017
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Cell reports
Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A
Tue Jul 11 00:00:00 EDT 2017
Guided self-organization and cortical plate formation in human brain organoids.
Nature biotechnology
Lancaster MA,Corsini NS,Wolfinger S,Gustafson EH,Phillips AW,Burkard TR,Otani T,Livesey FJ,Knoblich JA
Sat Jul 01 00:00:00 EDT 2017
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
Nature genetics
Lu H,Galeano MCR,Ott E,Kaeslin G,Kausalya PJ,Kramer C,Ortiz-Brüchle N,Hilger N,Metzis V,Hiersche M,Tay SY,Tunningley R,Vij S,Courtney AD,Whittle B,Wühl E,Vester U,Hartleben B,Neuber S,Frank V,Little MH,Epting D,Papathanasiou P,Perkins AC,Wright GD,Hunziker W,Gee HY,Otto EA,Zerres K,Hildebrandt F,Roy S,Wicking C,Bergmann C
Sat Jul 01 00:00:00 EDT 2017
Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model.
PloS one
Choi H,Shin JH,Kim ES,Park SJ,Bae IH,Jo YK,Jeong IY,Kim HJ,Lee Y,Park HC,Jeon HB,Kim KW,Lee TR,Cho DH
Wed Jun 28 00:00:00 EDT 2017
Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.
Journal of cellular physiology
Wang CY,Tsai HL,Syu JS,Chen TY,Su MT
Thu Jun 01 00:00:00 EDT 2017
An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations.
Scientific reports
Stayner C,Poole CA,McGlashan SR,Pilanthananond M,Brauning R,Markie D,Lett B,Slobbe L,Chae A,Johnstone AC,Jensen CG,McEwan JC,Dittmer K,Parker K,Wiles A,Blackburne W,Leichter A,Leask M,Pinnapureddy A,Jennings M,Horsfield JA,Walker RJ,Eccles MR
Tue May 09 00:00:00 EDT 2017
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.
Neural development
Rakotomamonjy J,Brunner M,Jüschke C,Zang K,Huang EJ,Reichardt LF,Chenn A
Mon May 08 00:00:00 EDT 2017
Cilia-dependent GLI processing in neural crest cells is required for tongue development.
Developmental biology
Millington G,Elliott KH,Chang YT,Chang CF,Dlugosz A,Brugmann SA
Sat Apr 15 00:00:00 EDT 2017
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders.
Journal of visualized experiments : JoVE
Gabriel E,Gopalakrishnan J
Fri Apr 14 00:00:00 EDT 2017
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
The Journal of cell biology
Yeyati PL,Schiller R,Mali G,Kasioulis I,Kawamura A,Adams IR,Playfoot C,Gilbert N,van Heyningen V,Wills J,von Kriegsheim A,Finch A,Sakai J,Schofield CJ,Jackson IJ,Mill P
Mon Apr 03 00:00:00 EDT 2017
Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro.
Cell and tissue research
Dores C,Alpaugh W,Su L,Biernaskie J,Dobrinski I
Sat Apr 01 00:00:00 EDT 2017
Estrogen receptor α is required for oviductal transport of embryos.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li S,O'Neill SR,Zhang Y,Holtzman MJ,Takemaru KI,Korach KS,Winuthayanon W
Sat Apr 01 00:00:00 EDT 2017
Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency.
Human genetics
Stephen J,Vilboux T,Mian L,Kuptanon C,Sinclair CM,Yildirimli D,Maynard DM,Bryant J,Fischer R,Vemulapalli M,Mullikin JC,Huizing M,Gahl WA,Malicdan MCV,Gunay-Aygun M
Sat Apr 01 00:00:00 EDT 2017
Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system.
Molecular biology of the cell
Katoh Y,Michisaka S,Nozaki S,Funabashi T,Hirano T,Takei R,Nakayama K
Sat Apr 01 00:00:00 EDT 2017
Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.
Molecular biology of the cell
Flanagan AM,Stavenschi E,Basavaraju S,Gaboriau D,Hoey DA,Morrison CG
Wed Mar 15 00:00:00 EDT 2017
Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.
Cell stem cell
Gabriel E,Ramani A,Karow U,Gottardo M,Natarajan K,Gooi LM,Goranci-Buzhala G,Krut O,Peters F,Nikolic M,Kuivanen S,Korhonen E,Smura T,Vapalahti O,Papantonis A,Schmidt-Chanasit J,Riparbelli M,Callaini G,Krönke M,Utermöhlen O,Gopalakrishnan J
Thu Mar 02 00:00:00 EST 2017
SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.
Developmental biology
Zhao L,Arsenault M,Ng ET,Longmuss E,Chau TC,Hartwig S,Koopman P
Wed Mar 01 00:00:00 EST 2017
Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.
Molecular biology of the cell
Funabashi T,Katoh Y,Michisaka S,Terada M,Sugawa M,Nakayama K
Wed Mar 01 00:00:00 EST 2017
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.
EMBO reports
Kobayashi T,Nakazono K,Tokuda M,Mashima Y,Dynlacht BD,Itoh H
Wed Feb 01 00:00:00 EST 2017
Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
Genes, brain, and behavior
Wang B,Zheng Y,Shi H,Du X,Zhang Y,Wei B,Luo M,Wang H,Wu X,Hua X,Sun M,Xu X
Wed Feb 01 00:00:00 EST 2017
Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.
Journal of cell science
Nozaki S,Katoh Y,Terada M,Michisaka S,Funabashi T,Takahashi S,Kontani K,Nakayama K
Wed Feb 01 00:00:00 EST 2017
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Nature communications
Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB
Mon Jan 30 00:00:00 EST 2017
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Cell
Phua SC,Chiba S,Suzuki M,Su E,Roberson EC,Pusapati GV,Schurmans S,Setou M,Rohatgi R,Reiter JF,Ikegami K,Inoue T
Thu Jan 12 00:00:00 EST 2017
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Cell
Phua SC,Chiba S,Suzuki M,Su E,Roberson EC,Pusapati GV,Schurmans S,Setou M,Rohatgi R,Reiter JF,Ikegami K,Inoue T
Thu Jan 12 00:00:00 EST 2017
Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.
Cellular and molecular neurobiology
Di Pietro C,Marazziti D,La Sala G,Abbaszadeh Z,Golini E,Matteoni R,Tocchini-Valentini GP
Sun Jan 01 00:00:00 EST 2017
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.
Journal of the American Society of Nephrology : JASN
Li Y,Tian X,Ma M,Jerman S,Kong S,Somlo S,Sun Z
Thu Dec 01 00:00:00 EST 2016
Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.
Journal of immunology (Baltimore, Md. : 1950)
Giridhar PV,Bell SM,Sridharan A,Rajavelu P,Kitzmiller JA,Na CL,Kofron M,Brandt EB,Ericksen M,Naren AP,Moon C,Khurana Hershey GK,Whitsett JA
Thu Dec 01 00:00:00 EST 2016
Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.
Neuroscience
Ramos RL,Toia AR,Pasternack DM,Dotzler TP,Cuoco JA,Esposito AW,Le MM,Parker AK,Goodman JH,Sarkisian MR
Sat Nov 19 00:00:00 EST 2016
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Cell reports
Fu W,Wang L,Kim S,Li J,Dynlacht BD
Tue Nov 01 00:00:00 EDT 2016
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Cell reports
Fu W,Wang L,Kim S,Li J,Dynlacht BD
Tue Nov 01 00:00:00 EDT 2016
Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.
PLoS genetics
Chang CF,Chang YT,Millington G,Brugmann SA
Tue Nov 01 00:00:00 EDT 2016
Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.
Cell reports
May-Simera HL,Gumerson JD,Gao C,Campos M,Cologna SM,Beyer T,Boldt K,Kaya KD,Patel N,Kretschmer F,Kelley MW,Petralia RS,Davey MG,Li T
Tue Oct 25 00:00:00 EDT 2016
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
PLoS genetics
Hong CJ,Hamilton BA
Sat Oct 01 00:00:00 EDT 2016
Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome.
Scientific reports
Duran I,Taylor SP,Zhang W,Martin J,Forlenza KN,Spiro RP,Nickerson DA,Bamshad M,Cohn DH,Krakow D
Mon Sep 26 00:00:00 EDT 2016
RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.
Biology open
Dutta N,Seo S
Thu Sep 15 00:00:00 EDT 2016
IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome.
Human molecular genetics
Zhang W,Taylor SP,Nevarez L,Lachman RS,Nickerson DA,Bamshad M,Krakow D,Cohn DH
Thu Sep 15 00:00:00 EDT 2016
IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome.
Human molecular genetics
Zhang W,Taylor SP,Nevarez L,Lachman RS,Nickerson DA,Bamshad M,Krakow D,Cohn DH
Thu Sep 15 00:00:00 EDT 2016
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.
Human molecular genetics
Paige Taylor S,Kunova Bosakova M,Varecha M,Balek L,Barta T,Trantirek L,Jelinkova I,Duran I,Vesela I,Forlenza KN,Martin JH,Hampl A,Bamshad M,Nickerson D,Jaworski ML,Song J,Ko HW,Cohn DH,Krakow D,Krejci P
Thu Sep 15 00:00:00 EDT 2016
KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
Scientific reports
Kim M,Suh YA,Oh JH,Lee BR,Kim J,Jang SJ
Tue Sep 06 00:00:00 EDT 2016
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.
Nature communications
Doobin DJ,Kemal S,Dantas TJ,Vallee RB
Wed Aug 24 00:00:00 EDT 2016
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Experimental neurology
Parker AK,Le MM,Smith TS,Hoang-Minh LB,Atkinson EW,Ugartemendia G,Semple-Rowland S,Coleman JE,Sarkisian MR
Mon Aug 01 00:00:00 EDT 2016
Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish.
Investigative ophthalmology & visual science
Song P,Dudinsky L,Fogerty J,Gaivin R,Perkins BD
Mon Aug 01 00:00:00 EDT 2016
Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.
Nature neuroscience
Wang L,Hou S,Han YG
Fri Jul 01 00:00:00 EDT 2016
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
Scientific reports
Lee SH,Lee MS,Choi TI,Hong H,Seo JY,Kim CH,Kim J
Mon Jun 06 00:00:00 EDT 2016
Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.
Cell stem cell
Parfitt DA,Lane A,Ramsden CM,Carr AF,Munro PM,Jovanovic K,Schwarz N,Kanuga N,Muthiah MN,Hull S,Gallo JM,da Cruz L,Moore AT,Hardcastle AJ,Coffey PJ,Cheetham ME
Thu Jun 02 00:00:00 EDT 2016
A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.
PloS one
Jiang S,Du J,Kong Q,Li C,Li Y,Sun H,Pu J,Mao B
Wed Jun 01 00:00:00 EDT 2016
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R
Fri May 13 00:00:00 EDT 2016
Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.
Human molecular genetics
Casey JP,Brennan K,Scheidel N,McGettigan P,Lavin PT,Carter S,Ennis S,Dorkins H,Ghali N,Blacque OE,Mc Gee MM,Murphy H,Lynch SA
Sun May 01 00:00:00 EDT 2016
Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium.
EMBO reports
Sánchez A,Urrego D,Pardo LA
Sun May 01 00:00:00 EDT 2016
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
Development (Cambridge, England)
Yadav SP,Sharma NK,Liu C,Dong L,Li T,Swaroop A
Sun May 01 00:00:00 EDT 2016
CPAP promotes timely cilium disassembly to maintain neural progenitor pool.
The EMBO journal
Gabriel E,Wason A,Ramani A,Gooi LM,Keller P,Pozniakovsky A,Poser I,Noack F,Telugu NS,Calegari F,Šarić T,Hescheler J,Hyman AA,Gottardo M,Callaini G,Alkuraya FS,Gopalakrishnan J
Fri Apr 15 00:00:00 EDT 2016
A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.
Cilia
Oud MM,Bonnard C,Mans DA,Altunoglu U,Tohari S,Ng AYJ,Eskin A,Lee H,Rupar CA,de Wagenaar NP,Wu KM,Lahiry P,Pazour GJ,Nelson SF,Hegele RA,Roepman R,Kayserili H,Venkatesh B,Siu VM,Reversade B,Arts HH
Tue Apr 12 00:00:00 EDT 2016
Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.
Nature cell biology
Li L,Grausam KB,Wang J,Lun MP,Ohli J,Lidov HG,Calicchio ML,Zeng E,Salisbury JL,Wechsler-Reya RJ,Lehtinen MK,Schüller U,Zhao H
Fri Apr 01 00:00:00 EDT 2016
Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
The Journal of biological chemistry
Hanke-Gogokhia C,Wu Z,Gerstner CD,Frederick JM,Zhang H,Baehr W
Fri Mar 25 00:00:00 EDT 2016
Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
The Journal of biological chemistry
Hanke-Gogokhia C,Wu Z,Gerstner CD,Frederick JM,Zhang H,Baehr W
Fri Mar 25 00:00:00 EDT 2016
Measuring the primary cilium length: improved method for unbiased high-throughput analysis.
Cilia
Dummer A,Poelma C,DeRuiter MC,Goumans MJ,Hierck BP
Fri Feb 12 00:00:00 EST 2016
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Oncotarget
Hoang-Minh LB,Deleyrolle LP,Siebzehnrubl D,Ugartemendia G,Futch H,Griffith B,Breunig JJ,De Leon G,Mitchell DA,Semple-Rowland S,Reynolds BA,Sarkisian MR
Tue Feb 09 00:00:00 EST 2016
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.
Journal of cell science
Kurtulmus B,Wang W,Ruppert T,Neuner A,Cerikan B,Viol L,Dueñas-Sánchez R,Gruss OJ,Pereira G
Mon Feb 01 00:00:00 EST 2016
NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.
Cell research
Zhang C,Zhang W,Lu Y,Yan X,Yan X,Zhu X,Liu W,Yang Y,Zhou T
Mon Feb 01 00:00:00 EST 2016
Endothelial primary cilia inhibit atherosclerosis.
EMBO reports
Dinsmore C,Reiter JF
Mon Feb 01 00:00:00 EST 2016
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Thompson CL,Wiles A,Poole CA,Knight MM
Mon Feb 01 00:00:00 EST 2016
Analysis of primary cilia in the developing mouse brain.
Methods in cell biology
Paridaen JT,Huttner WB,Wilsch-Bräuninger M
Tue Jan 26 00:00:00 EST 2016
Analysis of primary cilia in the developing mouse brain.
Methods in cell biology
Paridaen JT,Huttner WB,Wilsch-Bräuninger M
Tue Jan 26 00:00:00 EST 2016
Imaging centrosomes and cilia in the mouse kidney.
Methods in cell biology
Hoshi M,Wang J,Jain S,Mahjoub MR
Tue Jan 26 00:00:00 EST 2016
Arl13b and the exocyst interact synergistically in ciliogenesis.
Molecular biology of the cell
Seixas C,Choi SY,Polgar N,Umberger NL,East MP,Zuo X,Moreiras H,Ghossoub R,Benmerah A,Kahn RA,Fogelgren B,Caspary T,Lipschutz JH,Barral DC
Fri Jan 15 00:00:00 EST 2016
Arl13b and the exocyst interact synergistically in ciliogenesis.
Molecular biology of the cell
Seixas C,Choi SY,Polgar N,Umberger NL,East MP,Zuo X,Moreiras H,Ghossoub R,Benmerah A,Kahn RA,Fogelgren B,Caspary T,Lipschutz JH,Barral DC
Fri Jan 15 00:00:00 EST 2016
TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.
Nature cell biology
Lambacher NJ,Bruel AL,van Dam TJ,Szymańska K,Slaats GG,Kuhns S,McManus GJ,Kennedy JE,Gaff K,Wu KM,van der Lee R,Burglen L,Doummar D,Rivière JB,Faivre L,Attié-Bitach T,Saunier S,Curd A,Peckham M,Giles RH,Johnson CA,Huynen MA,Thauvin-Robinet C,Blacque OE
Fri Jan 01 00:00:00 EST 2016
MKS1 regulates ciliary INPP5E levels in Joubert syndrome.
Journal of medical genetics
Slaats GG,Isabella CR,Kroes HY,Dempsey JC,Gremmels H,Monroe GR,Phelps IG,Duran KJ,Adkins J,Kumar SA,Knutzen DM,Knoers NV,Mendelsohn NJ,Neubauer D,Mastroyianni SD,Vogt J,Worgan L,Karp N,Bowdin S,Glass IA,Parisi MA,Otto EA,Johnson CA,Hildebrandt F,van Haaften G,Giles RH,Doherty D
Fri Jan 01 00:00:00 EST 2016
MKS1 regulates ciliary INPP5E levels in Joubert syndrome.
Journal of medical genetics
Slaats GG,Isabella CR,Kroes HY,Dempsey JC,Gremmels H,Monroe GR,Phelps IG,Duran KJ,Adkins J,Kumar SA,Knutzen DM,Knoers NV,Mendelsohn NJ,Neubauer D,Mastroyianni SD,Vogt J,Worgan L,Karp N,Bowdin S,Glass IA,Parisi MA,Otto EA,Johnson CA,Hildebrandt F,van Haaften G,Giles RH,Doherty D
Fri Jan 01 00:00:00 EST 2016
The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
The Journal of biological chemistry
Singh J,Wen X,Scales SJ
Fri Dec 04 00:00:00 EST 2015
Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes.
Journal of medical genetics
Malicdan MC,Vilboux T,Stephen J,Maglic D,Mian L,Konzman D,Guo J,Yildirimli D,Bryant J,Fischer R,Zein WM,Snow J,Vemulapalli M,Mullikin JC,Toro C,Solomon BD,Niederhuber JE,Gahl WA,Gunay-Aygun M
Tue Dec 01 00:00:00 EST 2015
The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Structure (London, England : 1993)
Lokaj M,Kösling SK,Koerner C,Lange SM,van Beersum SE,van Reeuwijk J,Roepman R,Horn N,Ueffing M,Boldt K,Wittinghofer A
Tue Nov 03 00:00:00 EST 2015
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.
PLoS genetics
Yee LE,Garcia-Gonzalo FR,Bowie RV,Li C,Kennedy JK,Ashrafi K,Blacque OE,Leroux MR,Reiter JF
Sun Nov 01 00:00:00 EDT 2015
Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.
Nature communications
Bizet AA,Becker-Heck A,Ryan R,Weber K,Filhol E,Krug P,Halbritter J,Delous M,Lasbennes MC,Linghu B,Oakeley EJ,Zarhrate M,Nitschké P,Garfa-Traore M,Serluca F,Yang F,Bouwmeester T,Pinson L,Cassuto E,Dubot P,Elshakhs NAS,Sahel JA,Salomon R,Drummond IA,Gubler MC,Antignac C,Chibout S,Szustakowski JD,Hildebrandt F,Lorentzen E,Sailer AW,Benmerah A,Saint-Mezard P,Saunier S
Wed Oct 21 00:00:00 EDT 2015
Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Joiner AM,Green WW,McIntyre JC,Allen BL,Schwob JE,Martens JR
Wed Oct 07 00:00:00 EDT 2015
Culture and detection of primary cilia in endothelial cell models.
Cilia
Lim YC,McGlashan SR,Cooling MT,Long DS
Fri Oct 02 00:00:00 EDT 2015
PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism.
Journal of cell science
Nielsen BS,Malinda RR,Schmid FM,Pedersen SF,Christensen ST,Pedersen LB
Thu Oct 01 00:00:00 EDT 2015
Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome.
Journal of cellular biochemistry
Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY
Tue Sep 01 00:00:00 EDT 2015
A role for Rab23 in the trafficking of Kif17 to the primary cilium.
Journal of cell science
Lim YS,Tang BL
Sat Aug 15 00:00:00 EDT 2015
BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.
PloS one
Leitch CC,Zaghloul NA
Thu Aug 13 00:00:00 EDT 2015
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S
Tue Aug 11 00:00:00 EDT 2015
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S
Tue Aug 11 00:00:00 EDT 2015
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.
Nature cell biology
Wheway G,Schmidts M,Mans DA,Szymanska K,Nguyen TT,Racher H,Phelps IG,Toedt G,Kennedy J,Wunderlich KA,Sorusch N,Abdelhamed ZA,Natarajan S,Herridge W,van Reeuwijk J,Horn N,Boldt K,Parry DA,Letteboer SJF,Roosing S,Adams M,Bell SM,Bond J,Higgins J,Morrison EE,Tomlinson DC,Slaats GG,van Dam TJP,Huang L,Kessler K,Giessl A,Logan CV,Boyle EA,Shendure J,Anazi S,Aldahmesh M,Al Hazzaa S,Hegele RA,Ober C,Frosk P,Mhanni AA,Chodirker BN,Chudley AE,Lamont R,Bernier FP,Beaulieu CL,Gordon P,Pon RT,Donahue C,Barkovich AJ,Wolf L,Toomes C,Thiel CT,Boycott KM,McKibbin M,Inglehearn CF,Stewart F,Omran H,Huynen MA,Sergouniotis PI,Alkuraya FS,Parboosingh JS,Innes AM,Willoughby CE,Giles RH,Webster AR,Ueffing M,Blacque O,Gleeson JG,Wolfrum U,Beales PL,Gibson T,Doherty D,Mitchison HM,Roepman R,Johnson CA
Sat Aug 01 00:00:00 EDT 2015
Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis.
Cells
Majumder S,Cash A,Fisk HA
Fri Jul 31 00:00:00 EDT 2015
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Nature communications
Taylor SP,Dantas TJ,Duran I,Wu S,Lachman RS,Nelson SF,Cohn DH,Vallee RB,Krakow D
Tue Jun 16 00:00:00 EDT 2015
Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition.
Scientific reports
Rao KN,Li L,Anand M,Khanna H
Thu Jun 11 00:00:00 EDT 2015
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
Biochemical and biophysical research communications
Hong H,Kim J,Kim J
Fri May 22 00:00:00 EDT 2015
Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.
Scientific reports
Nygaard MB,Almstrup K,Lindbæk L,Christensen ST,Svingen T
Wed May 20 00:00:00 EDT 2015
Loss of primary cilia in melanoma cells is likely independent of proliferation and cell cycle progression.
The Journal of investigative dermatology
Snedecor ER,Sung CC,Moncayo A,Rothstein BE,Mockler DC,Tonnesen MG,Jones EC,Fujita M,Clark RA,Shroyer KR,Chen J
Fri May 01 00:00:00 EDT 2015
Centrin2 regulates CP110 removal in primary cilium formation.
The Journal of cell biology
Prosser SL,Morrison CG
Mon Mar 16 00:00:00 EDT 2015
The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.
Journal of cell science
Carpenter BS,Barry RL,Verhey KJ,Allen BL
Sun Mar 01 00:00:00 EST 2015
The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.
Cell reports
Miyamoto T,Hosoba K,Ochiai H,Royba E,Izumi H,Sakuma T,Yamamoto T,Dynlacht BD,Matsuura S
Tue Feb 10 00:00:00 EST 2015
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
The Journal of clinical investigation
Gainullin VG,Hopp K,Ward CJ,Hommerding CJ,Harris PC
Sun Feb 01 00:00:00 EST 2015
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Developmental biology
Lu H,Toh MT,Narasimhan V,Thamilselvam SK,Choksi SP,Roy S
Thu Jan 15 00:00:00 EST 2015
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
Nature communications
Kim H,Xu H,Yao Q,Li W,Huang Q,Outeda P,Cebotaru V,Chiaravalli M,Boletta A,Piontek K,Germino GG,Weinman EJ,Watnick T,Qian F
Tue Nov 18 00:00:00 EST 2014
Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.
PloS one
Lee JY,Hong WJ,Majeti R,Stearns T
Tue Nov 18 00:00:00 EST 2014
Primary cilia in the developing pig testis.
Cell and tissue research
Ou Y,Dores C,Rodriguez-Sosa JR,van der Hoorn FA,Dobrinski I
Sat Nov 01 00:00:00 EDT 2014
A homozygous missense mutation in the ciliary gene TTC21B causes familial FSGS.
Journal of the American Society of Nephrology : JASN
Huynh Cong E,Bizet AA,Boyer O,Woerner S,Gribouval O,Filhol E,Arrondel C,Thomas S,Silbermann F,Canaud G,Hachicha J,Ben Dhia N,Peraldi MN,Harzallah K,Iftene D,Daniel L,Willems M,Noel LH,Bole-Feysot C,Nitschké P,Gubler MC,Mollet G,Saunier S,Antignac C
Sat Nov 01 00:00:00 EDT 2014
A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.
PLoS genetics
Swiderski RE,Nakano Y,Mullins RF,Seo S,Bánfi B
Wed Oct 01 00:00:00 EDT 2014
Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.
The Journal of cell biology
Kong D,Farmer V,Shukla A,James J,Gruskin R,Kiriyama S,Loncarek J
Mon Sep 29 00:00:00 EDT 2014
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Nature cell biology
Jin D,Ni TT,Sun J,Wan H,Amack JD,Yu G,Fleming J,Chiang C,Li W,Papierniak A,Cheepala S,Conseil G,Cole SP,Zhou B,Drummond IA,Schuetz JD,Malicki J,Zhong TP
Mon Sep 01 00:00:00 EDT 2014
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Nature cell biology
Jin D,Ni TT,Sun J,Wan H,Amack JD,Yu G,Fleming J,Chiang C,Li W,Papierniak A,Cheepala S,Conseil G,Cole SP,Zhou B,Drummond IA,Schuetz JD,Malicki J,Zhong TP
Mon Sep 01 00:00:00 EDT 2014
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.
eLife
Wang W,Wu T,Kirschner MW
Tue Aug 19 00:00:00 EDT 2014
Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy.
American journal of human genetics
Roosing S,Lamers IJ,de Vrieze E,van den Born LI,Lambertus S,Arts HH,Peters TA,Hoyng CB,Kremer H,Hetterschijt L,Letteboer SJ,van Wijk E,Roepman R,den Hollander AI,Cremers FP
Thu Aug 07 00:00:00 EDT 2014
Arhgap36-dependent activation of Gli transcription factors.
Proceedings of the National Academy of Sciences of the United States of America
Rack PG,Ni J,Payumo AY,Nguyen V,Crapster JA,Hovestadt V,Kool M,Jones DT,Mich JK,Firestone AJ,Pfister SM,Cho YJ,Chen JK
Tue Jul 29 00:00:00 EDT 2014
Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.
Proceedings of the National Academy of Sciences of the United States of America
Čajánek L,Nigg EA
Tue Jul 15 00:00:00 EDT 2014
Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division.
eLife
Mora-Bermúdez F,Matsuzaki F,Huttner WB
Fri Jul 04 00:00:00 EDT 2014
Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.
Nature communications
Veleri S,Manjunath SH,Fariss RN,May-Simera H,Brooks M,Foskett TA,Gao C,Longo TA,Liu P,Nagashima K,Rachel RA,Li T,Dong L,Swaroop A
Fri Jun 20 00:00:00 EDT 2014
Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion.
Molecular biology of the cell
Aguilar A,Becker L,Tedeschi T,Heller S,Iomini C,Nachury MV
Sun Jun 15 00:00:00 EDT 2014
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
The EMBO journal
Chaya T,Omori Y,Kuwahara R,Furukawa T
Mon Jun 02 00:00:00 EDT 2014
Basal body proteins regulate Notch signaling through endosomal trafficking.
Journal of cell science
Leitch CC,Lodh S,Prieto-Echagüe V,Badano JL,Zaghloul NA
Sun Jun 01 00:00:00 EDT 2014
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.
Cell metabolism
Stratigopoulos G,Martin Carli JF,O'Day DR,Wang L,Leduc CA,Lanzano P,Chung WK,Rosenbaum M,Egli D,Doherty DA,Leibel RL
Tue May 06 00:00:00 EDT 2014
RFX7 is required for the formation of cilia in the neural tube.
Mechanisms of development
Manojlovic Z,Earwood R,Kato A,Stefanovic B,Kato Y
Thu May 01 00:00:00 EDT 2014
SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.
Human molecular genetics
Zhou X,Fan LX,Li K,Ramchandran R,Calvet JP,Li X
Sat Mar 15 00:00:00 EDT 2014
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.
Osteoarthritis and cartilage
Thompson CL,Chapple JP,Knight MM
Sat Mar 01 00:00:00 EST 2014
Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.
American journal of human genetics
Halbritter J,Bizet AA,Schmidts M,Porath JD,Braun DA,Gee HY,McInerney-Leo AM,Krug P,Filhol E,Davis EE,Airik R,Czarnecki PG,Lehman AM,Trnka P,Nitschké P,Bole-Feysot C,Schueler M,Knebelmann B,Burtey S,Szabó AJ,Tory K,Leo PJ,Gardiner B,McKenzie FA,Zankl A,Brown MA,Hartley JL,Maher ER,Li C,Leroux MR,Scambler PJ,Zhan SH,Jones SJ,Kayserili H,Tuysuz B,Moorani KN,Constantinescu A,Krantz ID,Kaplan BS,Shah JV,Hurd TW,Doherty D,Katsanis N,Duncan EL,Otto EA,Beales PL,Mitchison HM,Saunier S,Hildebrandt F
Thu Nov 07 00:00:00 EST 2013
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.
Nature methods
Su S,Phua SC,DeRose R,Chiba S,Narita K,Kalugin PN,Katada T,Kontani K,Takeda S,Inoue T
Fri Nov 01 00:00:00 EDT 2013
Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division.
Cell
Paridaen JT,Wilsch-Bräuninger M,Huttner WB
Thu Oct 10 00:00:00 EDT 2013
Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division.
Cell
Paridaen JT,Wilsch-Bräuninger M,Huttner WB
Thu Oct 10 00:00:00 EDT 2013
Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.
The Journal of clinical investigation
Drivas TG,Holzbaur EL,Bennett J
Tue Oct 01 00:00:00 EDT 2013
The ciliary protein Ftm is required for ventricular wall and septal development.
PloS one
Gerhardt C,Lier JM,Kuschel S,Rüther U
Tue Sep 10 00:00:00 EDT 2013
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.
Science (New York, N.Y.)
Bhogaraju S,Cajanek L,Fort C,Blisnick T,Weber K,Taschner M,Mizuno N,Lamla S,Bastin P,Nigg EA,Lorentzen E
Fri Aug 30 00:00:00 EDT 2013
Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.
American journal of human genetics
Davidson AE,Schwarz N,Zelinger L,Stern-Schneider G,Shoemark A,Spitzbarth B,Gross M,Laxer U,Sosna J,Sergouniotis PI,Waseem NH,Wilson R,Kahn RA,Plagnol V,Wolfrum U,Banin E,Hardcastle AJ,Cheetham ME,Sharon D,Webster AR
Thu Aug 08 00:00:00 EDT 2013
Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis.
Human molecular genetics
Liu C,Lin C,Whitaker DT,Bakeri H,Bulgakov OV,Liu P,Lei J,Dong L,Li T,Swaroop A
Sat Jun 01 00:00:00 EDT 2013
Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys.
American journal of physiology. Renal physiology
Kim JI,Kim J,Jang HS,Noh MR,Lipschutz JH,Park KM
Wed May 15 00:00:00 EDT 2013
CCDC41 is required for ciliary vesicle docking to the mother centriole.
Proceedings of the National Academy of Sciences of the United States of America
Joo K,Kim CG,Lee MS,Moon HY,Lee SH,Kim MJ,Kweon HS,Park WY,Kim CH,Gleeson JG,Kim J
Tue Apr 09 00:00:00 EDT 2013
VDAC3 and Mps1 negatively regulate ciliogenesis.
Cell cycle (Georgetown, Tex.)
Majumder S,Fisk HA
Fri Mar 01 00:00:00 EST 2013
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.
The Journal of cell biology
Kuhns S,Schmidt KN,Reymann J,Gilbert DF,Neuner A,Hub B,Carvalho R,Wiedemann P,Zentgraf H,Erfle H,Klingmüller U,Boutros M,Pereira G
Mon Feb 18 00:00:00 EST 2013
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
Cell
Mukhopadhyay S,Wen X,Ratti N,Loktev A,Rangell L,Scales SJ,Jackson PK
Thu Jan 17 00:00:00 EST 2013
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
Proceedings of the National Academy of Sciences of the United States of America
Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S
Tue Nov 27 00:00:00 EST 2012
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
Proceedings of the National Academy of Sciences of the United States of America
Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S
Tue Nov 27 00:00:00 EST 2012
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
The Journal of cell biology
Li Y,Zhang Q,Wei Q,Zhang Y,Ling K,Hu J
Mon Nov 12 00:00:00 EST 2012
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
The Journal of cell biology
Li Y,Zhang Q,Wei Q,Zhang Y,Ling K,Hu J
Mon Nov 12 00:00:00 EST 2012
Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination.
Development (Cambridge, England)
Wilsch-Bräuninger M,Peters J,Paridaen JT,Huttner WB
Sun Jan 01 00:00:00 EST 2012
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Nature cell biology
Chih B,Liu P,Chinn Y,Chalouni C,Komuves LG,Hass PE,Sandoval W,Peterson AS
Sun Dec 18 00:00:00 EST 2011
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
PLoS genetics
Seo S,Zhang Q,Bugge K,Breslow DK,Searby CC,Nachury MV,Sheffield VC
Tue Nov 01 00:00:00 EDT 2011
