Product References
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.
Cell reports
Schleinitz A,Pöttgen LA,Keren-Kaplan T,Pu J,Saftig P,Bonifacino JS,Haas A,Jeschke A
Tue Jan 31 00:00:00 EST 2023
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.
Cell reports
Schleinitz A,Pöttgen LA,Keren-Kaplan T,Pu J,Saftig P,Bonifacino JS,Haas A,Jeschke A
Tue Jan 31 00:00:00 EST 2023
A program of successive gene expression in mouse one-cell embryos.
Cell reports
Asami M,Lam BYH,Hoffmann M,Suzuki T,Lu X,Yoshida N,Ma MK,Rainbow K,Gužvić M,VerMilyea MD,Yeo GSH,Klein CA,Perry ACF
Tue Jan 31 00:00:00 EST 2023
Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila.
iScience
Inoshita T,Liu JY,Taniguchi D,Ishii R,Shiba-Fukushima K,Hattori N,Imai Y
Thu Dec 22 00:00:00 EST 2022
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
Frontiers in cellular neuroscience
Bauer CS,Webster CP,Shaw AC,Kok JR,Castelli LM,Lin YH,Smith EF,Illanes-Álvarez F,Higginbottom A,Shaw PJ,Azzouz M,Ferraiuolo L,Hautbergue GM,Grierson AJ,De Vos KJ
Wed Aug 16 00:00:00 EDT 2023
The Salmonella effector SifA initiates a kinesin-1 and kinesin-3 recruitment process mirroring that mediated by Arl8a and Arl8b.
Journal of cell science
Fang Z,Fallet M,Moest T,Gorvel JP,Méresse S
Thu Dec 01 00:00:00 EST 2022
RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin.
Nature communications
Keren-Kaplan T,Sarić A,Ghosh S,Williamson CD,Jia R,Li Y,Bonifacino JS
Mon Mar 21 00:00:00 EDT 2022
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Developmental cell
Roney JC,Li S,Farfel-Becker T,Huang N,Sun T,Xie Y,Cheng XT,Lin MY,Platt FM,Sheng ZH
Mon May 17 00:00:00 EDT 2021
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Developmental cell
Roney JC,Li S,Farfel-Becker T,Huang N,Sun T,Xie Y,Cheng XT,Lin MY,Platt FM,Sheng ZH
Mon May 17 00:00:00 EDT 2021
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Developmental cell
Roney JC,Li S,Farfel-Becker T,Huang N,Sun T,Xie Y,Cheng XT,Lin MY,Platt FM,Sheng ZH
Mon May 17 00:00:00 EDT 2021
ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1.
Current biology : CB
Keren-Kaplan T,Bonifacino JS
Mon Feb 08 00:00:00 EST 2021
mTORC1 activity is supported by spatial association with focal adhesions.
The Journal of cell biology
Rabanal-Ruiz Y,Byron A,Wirth A,Madsen R,Sedlackova L,Hewitt G,Nelson G,Stingele J,Wills JC,Zhang T,Zeug A,Fässler R,Vanhaesebroeck B,Maddocks ODK,Ponimaskin E,Carroll B,Korolchuk VI
Mon May 03 00:00:00 EDT 2021
Specific KIF1A-adaptor interactions control selective cargo recognition.
The Journal of cell biology
Hummel JJA,Hoogenraad CC
Mon Oct 04 00:00:00 EDT 2021
Endosomal sorting drives the formation of axonal prion protein endoggresomes.
Science advances
Chassefeyre R,Chaiamarit T,Verhelle A,Novak SW,Andrade LR,Leitão ADG,Manor U,Encalada SE
Fri Dec 24 00:00:00 EST 2021
Endosomal sorting drives the formation of axonal prion protein endoggresomes.
Science advances
Chassefeyre R,Chaiamarit T,Verhelle A,Novak SW,Andrade LR,Leitão ADG,Manor U,Encalada SE
Fri Dec 24 00:00:00 EST 2021
The GTPase Arl8B Plays a Principle Role in the Positioning of Interstitial Axon Branches by Spatially Controlling Autophagosome and Lysosome Location.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Adnan G,Rubikaite A,Khan M,Reber M,Suetterlin P,Hindges R,Drescher U
Wed Oct 14 00:00:00 EDT 2020
The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes.
Science advances
Lu M,van Tartwijk FW,Lin JQ,Nijenhuis W,Parutto P,Fantham M,Christensen CN,Avezov E,Holt CE,Tunnacliffe A,Holcman D,Kapitein L,Schierle GSK,Kaminski CF
Tue Dec 01 00:00:00 EST 2020
Hepatitis C virus infection increases autophagosome stability by suppressing lysosomal fusion through an Arl8b-dependent mechanism.
The Journal of biological chemistry
Jones-Jamtgaard KN,Wozniak AL,Koga H,Ralston R,Weinman SA
Fri Sep 27 00:00:00 EDT 2019
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.
Cell reports
Farfel-Becker T,Roney JC,Cheng XT,Li S,Cuddy SR,Sheng ZH
Tue Jul 02 00:00:00 EDT 2019
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.
Cell reports
Farfel-Becker T,Roney JC,Cheng XT,Li S,Cuddy SR,Sheng ZH
Tue Jul 02 00:00:00 EDT 2019
BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon.
Proceedings of the National Academy of Sciences of the United States of America
Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS
Tue Apr 04 00:00:00 EDT 2017
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.
The Journal of cell biology
Schiefermeier N,Scheffler JM,de Araujo ME,Stasyk T,Yordanov T,Ebner HL,Offterdinger M,Munck S,Hess MW,Wickström SA,Lange A,Wunderlich W,Fässler R,Teis D,Huber LA
Mon May 26 00:00:00 EDT 2014
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.
The Journal of cell biology
Schiefermeier N,Scheffler JM,de Araujo ME,Stasyk T,Yordanov T,Ebner HL,Offterdinger M,Munck S,Hess MW,Wickström SA,Lange A,Wunderlich W,Fässler R,Teis D,Huber LA
Mon May 26 00:00:00 EDT 2014
Lysosomal positioning coordinates cellular nutrient responses.
Nature cell biology
Korolchuk VI,Saiki S,Lichtenberg M,Siddiqi FH,Roberts EA,Imarisio S,Jahreiss L,Sarkar S,Futter M,Menzies FM,O'Kane CJ,Deretic V,Rubinsztein DC
Fri Apr 01 00:00:00 EDT 2011
Lysosomal positioning coordinates cellular nutrient responses.
Nature cell biology
Korolchuk VI,Saiki S,Lichtenberg M,Siddiqi FH,Roberts EA,Imarisio S,Jahreiss L,Sarkar S,Futter M,Menzies FM,O'Kane CJ,Deretic V,Rubinsztein DC
Fri Apr 01 00:00:00 EDT 2011
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Cellular microbiology
Kaniuk NA,Canadien V,Bagshaw RD,Bakowski M,Braun V,Landekic M,Mitra S,Huang J,Heo WD,Meyer T,Pelletier L,Andrews-Polymenis H,McClelland M,Pawson T,Grinstein S,Brumell JH
Tue Nov 01 00:00:00 EDT 2011
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Cellular microbiology
Kaniuk NA,Canadien V,Bagshaw RD,Bakowski M,Braun V,Landekic M,Mitra S,Huang J,Heo WD,Meyer T,Pelletier L,Andrews-Polymenis H,McClelland M,Pawson T,Grinstein S,Brumell JH
Tue Nov 01 00:00:00 EDT 2011
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Cellular microbiology
Kaniuk NA,Canadien V,Bagshaw RD,Bakowski M,Braun V,Landekic M,Mitra S,Huang J,Heo WD,Meyer T,Pelletier L,Andrews-Polymenis H,McClelland M,Pawson T,Grinstein S,Brumell JH
Tue Nov 01 00:00:00 EDT 2011
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Cellular microbiology
Kaniuk NA,Canadien V,Bagshaw RD,Bakowski M,Braun V,Landekic M,Mitra S,Huang J,Heo WD,Meyer T,Pelletier L,Andrews-Polymenis H,McClelland M,Pawson T,Grinstein S,Brumell JH
Tue Nov 01 00:00:00 EDT 2011
