Immunogen sequence: MAEGDNRST NLLAAETASL EEQLQGWGEV MLMADKVLRW ERAWFPPAIM GVVSLVFLII YYLDPSVLSG VSCFVMFLCL ADYLVPILAP RIFGSNKWTT EQQQRFHEIC SNLVKTRRRA VGWWKRLFTL KEEKPKMYFM TMIVSLAAVA WVGQQVHNLL LTYLIVTSLL LLPGLNQHGI ILKYIGMAKR EINKLLKQKE KKNE (1-203 aa encoded by BC010281)
Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
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Protein Aliases: ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation-like factor 6 interacting protein; ADP-ribosylation-like factor 6-interacting protein; aip-1; Apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Protein TBX2
Gene Aliases: Aip-1; AIP-6; AIP1; AL022945; ARL6IP; ARL6IP1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; SPG61
Molecular Function: non-receptor serine/threonine protein kinase