A suggested positive control is mouse small intestine tissue lysate.
PA5-20061 can be used with blocking peptide PEP-0180.
Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation-like factor 6 interacting protein; aip-1; Apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Protein TBX2
Gene Aliases: Aip-1; AIP-6; AIP1; AL022945; ARL6IP; ARL6IP1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; SPG61