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Product Details
PA5-20061
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Ion-exchange chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152518
Product Specific Information
A suggested positive control is mouse small intestine tissue lysate.^M
^M
PA5-20061 can be used with blocking peptide PEP-0180.
Target Information
Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation-like factor 6 interacting protein; aip-1; Apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Protein TBX2
Gene Aliases: Aip-1; AIP-6; AIP1; AL022945; ARL6IP; ARL6IP1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; SPG61
UniProt ID: (Human) Q15041, (Mouse) Q9JKW0
Entrez Gene ID: (Human) 23204, (Mouse) 54208
positive regulation of L-glutamate transport
cotranslational protein targeting to membrane
apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
endoplasmic reticulum tubular network assembly
endoplasmic reticulum tubular network membrane organization
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