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Product Details
MANF-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 80-120 on human Mesencephalic astrocyte-derived neurotrophic factor.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is localized in the endoplasmic reticulum and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arginine-rich protein; arginine-rich, mutated in early stage tumors; Mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET
Gene Aliases: 3230402M22Rik; AA407711; AA408789; AA673178; ARMET; ARP; D17914; D18Mgi17; MANF
UniProt ID: (Human) P55145, (Mouse) Q9CXI5
Entrez Gene ID: (Human) 7873, (Mouse) 74840, (Rat) 315989
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