Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human ARNT2.
Immunogen sequence: QDLLGKDIL EFCHPEDQSH LRESFQQVVK LKGQVLSVMY RFRTKNREWM LIRTSSFTFQ NPYSDEIEYI ICTNTNVKQL QQQQAELEVH QRDGLSSYDL SQVPVPNLPA GVHEAGKSVE KADAIFSQER DPRFAEMFAG ISASEKKMMS SASAAGTQQI YSQGSPFPSG HSGKAFSSSV VHVPGVNDIQ SSSSTGQNMS QISRQLNQSQ VAWTGSRPPF PGQQIPSQSS KTQSSPFGIG TSHTYPADPS SYSPLSSPAT SSPSGNAYSS LANRTPGFAE SGQSSGQFQG RPSEVWSQWQ SQHHGQQSGE QHSHQQPGQT EVFQDMLPMP GDPGNEWWSP HSRQHFRQPI SYARM (363-716 aa encoded by BC036099)
AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARNT 2; ARNT protein 2; Aryl hydrocarbon receptor nuclear translocator 2; aryl-hydrocarbon receptor nuclear translocator 2; bHLHe1; Class E basic helix-loop-helix protein 1
Gene Aliases: ARNT2; BHLHE1; Hif-2b; KIAA0307; mKIAA0307; WEDAS
UniProt ID: (Human) Q9HBZ2, (Mouse) Q61324, (Rat) Q78E60
Entrez Gene ID: (Human) 9915, (Mouse) 11864, (Rat) 25243
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