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ARP2/ARP3 Polyclonal Antibody
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Product Details
BS-12524R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ARP2/ARP3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Actin polymerization is required for a variety of cell functions, including chemotaxis, cell migration, cell adhesion, and platelet activation. Cells trigger actin polymerization through either the de novo nucleation of filaments from monomeric actin, the severing of existing filaments to create uncapped barbed ends, or the uncapping of existing barbed ends. The nucleation of actin is a rate-limiting and unfavorable reaction in actin polymerization and therefore requires the involvement of the Arp2/3 complex, which helps create new filaments and promotes the end-to-side cross-linking of actin filaments into the branching meshwork. The Arp2/3 complex consists of the actin-related proteins Arp2 and Arp3, and various other accessory proteins. The Arp2/3 complex promotes actin nucleation by binding the pointed end of actin filaments, or by associating with the side of an existing filament, and nucleates growth in the barbed direction. In addition, the Arp2/3 complex also mediates actin cytoskeletal outgrowths that are regulated by the Rho family of small GTPases. In response to GTP-binding Cdc42, the Arp2/3 complex binds the Cdc42 substrates, namely the WASP proteins, and initiates the formation of lamellipodia and filopodia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-like protein 2; Actin-like protein 3; Actin-related protein 2; Actin-related protein 3; actin-related protein 3 homolog (yest); ARP2 actin related protein 2 homolog; ARP2 actin-related protein 2 homolog; ARP3 actin related protein 3 homolog; ARP3 actin-related protein 3 homolog; one of seven subunits of the Arp2/3 protein complex; unnamed protein product
Gene Aliases: 1200003A09Rik; 4921510D23Rik; AA409782; ACTR2; ACTR3; ARP2; ARP3; D6Ertd746e
UniProt ID: (Human) P61160, (Human) P61158, (Rat) Q5M7U6, (Mouse) P61161, (Rat) Q4V7C7, (Mouse) Q99JY9
Entrez Gene ID: (Human) 10097, (Human) 10096, (Rat) 289820, (Mouse) 66713, (Rat) 81732, (Mouse) 74117
establishment or maintenance of cell polarity
asymmetric cell division
positive regulation of lamellipodium assembly
meiotic chromosome movement towards spindle pole
cytosolic transport
actin cytoskeleton organization
meiotic cytokinesis
Arp2/3 complex-mediated actin nucleation
positive regulation of transcription from RNA polymerase II promoter
meiotic cell cycle
spindle localization
cilium morphogenesis
cellular response to interferon-gamma
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair via nonhomologous end joining
cell projection organization
actin polymerization-dependent cell motility
cilium assembly
actin filament organization
response to carbohydrate
positive regulation of actin filament polymerization
regulation of myosin II filament organization
positive regulation of neuron differentiation
response to antibiotic
positive regulation of dendrite morphogenesis
positive regulation of filopodium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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