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Proteintech
ARRDC1 Polyclonal Antibody
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Product Details
21030-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARRDC1 fusion protein Ag15341
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: HSFPFQFLLP ATAPTSFEGP FGKIVHQVRA AIHTPRFSKD HKCSLVFYIL SPLNLNSIPD IEQPNVASAT KKFSYKLVKT GSVVLTASTD LRGYVVGQAL QLHADVENQS GKDTSPVVAS LLQKVSYKAK RWIHDVRTIA EVEGAGVKAW RRAQWHEQIL VPALPQSALP GCSLIHIDYY LQVSLKAPEA TVTLPVFIGN IAVNHAPVSP RPGLGLPPGA PPLVVPSAPP QEEAEAEAAA GGPHFLDPVF LSTKSHSQRQ PLLATLSSVP GAPEPCPQDG SPASHPLHPP LCISTGATVP YFAEGSGGPV PTTSTLILPP EYSSWGYPYE APPSYEQSCG GVEPSLTPES
Target Information
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-arrestin 1; Arrestin domain-containing protein 1
Gene Aliases: ARRDC1
UniProt ID: (Human) Q8N5I2
Entrez Gene ID: (Human) 92714
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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