Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis of activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha-arrestin 3; Arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; thioredoxin-binding protein-2-like inducible membrane; TLIMP
Gene Aliases: AI450344; ARRDC3; KIAA1376; mKIAA1376; TLIMP