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Invitrogen
ARS2 Polyclonal Antibody
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Product Details
PA5-143072
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-DPRAIVEYRDLDAPD.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognize all reported isoform (NP_056992.4; NP_001122324.1; NP_001122325.1; NP_001122326.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; Arsenite-resistance protein 2; Serrate RNA effector molecule homolog; similar to arsenate resistance protein 2
Gene Aliases: 2810019G02Rik; ARS2; ASR2; ASR2A; ASR2B; ASR2C; ASR2D; serrate; SRRT
UniProt ID: (Human) Q9BXP5, (Mouse) Q99MR6
Entrez Gene ID: (Rat) 686980, (Human) 51593, (Mouse) 83701
transcription, DNA-templated
regulation of transcription, DNA-templated
cell proliferation
gene silencing by RNA
primary miRNA processing
neuronal stem cell population maintenance
mRNA splicing, via spliceosome
snRNA transcription from RNA polymerase II promoter
response to arsenic-containing substance
positive regulation of neurogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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