Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: VNAYALNSIA LHILYIVCQE YRKTSNKELR HLIEVSVVLW AVALTSWISD
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 79%; Dog: 92%; Guinea Pig: 75%; Human: 100%; Pig: 85%; Rabbit: 86%; Rat: 77%
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3.5.1.23; Acylsphingosine deacylase 3; alkaline CDase 1; Alkaline ceramidase 1; AlkCDase 1; CTB-180A7.3; N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; N-acylsphingosine amidohydrolase 3
Gene Aliases: ACER1; ALKCDase1; ASAH3
UniProt ID: (Human) Q8TDN7
Entrez Gene ID: (Human) 125981
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