Immunogen sequence: STPRDKQRLS YGAFTNQIFV STSTDSPTSP TTEAPPLPPR NAGKGNDGGP SSSSKTTNKF EGLSQQSSTS SAKTALGPRV LPKLPQKVAL RKT
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 95%.
ASAP1, also known as Development and differentiation enhancing factor 1, is a protein with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. ASAP1 is a homodimer known to interact with SRC and CRK and its activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2). It possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. It may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2 and may also function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. It is widely expressed in most of the tissues. ASAP1 is a protooncogene involved in invasive breast cancer and in other types of invasive and malignant tumors, such as uveal melanomas.
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Protein Aliases: 130 kDa phosphatidylinositol 4; 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; 5-biphosphate-dependent ARF1 GTPase-activating protein; 5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; AMAP1; ANK repeat and PH domain-containing protein 1; ARF GTPase-activating protein 1; arf-GAP with SH3 domain; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; beta 4; centaurin; centaurin, beta 4; CENTB4; DDEF1; DEF-1; Development and differentiation-enhancing factor 1; PAG2; PIP2-dependent ARF1 GAP; ZG14P
Gene Aliases: AMAP1; ASAP1; CENTB4; DDEF1; KIAA1249; PAG2; PAP; ZG14P
UniProt ID: (Human) Q9ULH1
Entrez Gene ID: (Human) 50807