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Immunogen sequence: PKPGELPPKP QLGDLPPKPQ LSDLPPKPQM KDLPPKPQLG DLLAKSQTGD VSPKAQQPSE VTLKSHPLDL SPNVQSRDAI QKQASEDSND LTPTLPETPV PLPRKINTGK NKVRRVKTIY DC
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 92%.
ASAP1, also known as Development and differentiation enhancing factor 1, is a protein with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. ASAP1 is a homodimer known to interact with SRC and CRK and its activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2). It possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. It may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2 and may also function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. It is widely expressed in most of the tissues. ASAP1 is a protooncogene involved in invasive breast cancer and in other types of invasive and malignant tumors, such as uveal melanomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; centaurin, beta 4; DEF-1; Development and differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP
Gene Aliases: AMAP1; ASAP1; CENTB4; DDEF1; KIAA1249; PAG2; PAP; ZG14P
UniProt ID: (Human) Q9ULH1
Entrez Gene ID: (Human) 50807