This antibody may cross react with mouse and rat Asb-2, based on sequence homology.
Suggested positive control: human spleen protein, human lung or spleen, human lung protein.
The ankyrin repeat and SOCS box-containing (Asb) protein family is comprised of members which each contain “SOCS boxes” but differ from other families of protein in the motifs they contain upstream of the SOCS box(1). SOCS boxes are carboxy-terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. Asb-2 has been found to induce growth inhibition and chromatin condensation in myeloid leukemia cells(2).
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Protein Aliases: Ankyrin repeat and SOCS box protein 2; ankyrin repeat and SOCS box-containing protein 2a; ASB-2; MGC40044
Gene Aliases: ASB-2; ASB2
UniProt ID: (Human) Q96Q27
Entrez Gene ID: (Human) 51676