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The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described.
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Protein Aliases: Ankyrin repeat and SOCS box protein 7; ankyrin repeat and SOCS box-containing 7; ankyrin repeat and SOCS box-containing protein 7; ASB-7
Gene Aliases: AI449039; Asb-7; ASB7; D030055C23Rik
UniProt ID: (Human) Q9H672, (Mouse) Q91ZU0
Entrez Gene ID: (Human) 140460, (Mouse) 117589, (Rat) 365277
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