Invitrogen

ASCL1 Polyclonal Antibody

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ASCL1 Polyclonal Antibody

Product Details

PA5-143052

Applications
Tested Dilution
Publications

Western Blot (WB)

0.3-1 µg/mL
-

Immunocytochemistry (ICC/IF)

10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-HKSAPKQVKRQRS.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2933691

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor that is required for early development of the nervous system. Expressed in fetal brain, ASCL1 is essential for the proper development of autonomic neurons and for the survival of subsets of autonomic neurons. ASCL1 interaction with MEF-2A may regulate the expression of specific genes that are critical for the formation of distinct neuronal circuits within the central nervous system. The high level of ASCL1 expression in neuroendocrine tumors, such as medullary thyroid cancer, small cell lung cancer and lung cancer with neuroendocrine features may provide a useful marker for cancers with neuroendocrine features. Mapping to human chromosome 12, the ASCL1 gene contains a trinucleotide repeat region, making this locus a candidate for inherited disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: achaete scute protein; achaete-scute complex homolog 1; achaete-scute complex homolog-like 1; achaete-scute complex-like 1; achaete-scute complex-like protein 1; Achaete-scute homolog 1; ASH-1; bHLHa46; Class A basic helix-loop-helix protein 46; KMT2H; mammalian achaete scute homolog 1; mASH-1

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Gene Aliases: AI225900; ASCL1; ASH1; BHLHA46; HASH1; Mash-1; MASH1

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UniProt ID: (Human) P50553, (Rat) P19359, (Mouse) Q02067

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Entrez Gene ID: (Human) 429, (Rat) 64186, (Mouse) 17172

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, transcription factor binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding protein homodimerization activity bHLH transcription factor binding E-box binding double-stranded DNA binding sequence-specific DNA binding protein dimerization activity basic helix-loop-helix transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter neuron migration noradrenergic neuron development noradrenergic neuron fate commitment transcription, DNA-templated Notch signaling pathway regulation of mitotic cell cycle neuroblast fate determination neuroblast proliferation response to lithium ion regulation of gene expression oligodendrocyte development spinal cord association neuron differentiation spinal cord oligodendrocyte cell fate specification vestibular nucleus development cerebral cortex GABAergic interneuron differentiation commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron development cerebral cortex development neurogenesis regulation of epithelial cell differentiation response to retinoic acid negative regulation of apoptotic process positive regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of Notch signaling pathway positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation sympathetic nervous system development neuron fate specification musculoskeletal movement, spinal reflex action response to folic acid subpallium neuron fate commitment regulation of timing of subpallium neuron differentiation olfactory pit development lung epithelial cell differentiation ventral spinal cord interneuron fate commitment lung neuroendocrine cell differentiation stomach neuroendocrine cell differentiation carotid body glomus cell differentiation adrenal chromaffin cell differentiation sympathetic ganglion development response to epidermal growth factor cellular response to magnetism positive regulation of neural precursor cell proliferation regulation of transcription from RNA polymerase II promoter pattern specification process nervous system development regulation of Notch signaling pathway glial cell differentiation spinal cord oligodendrocyte cell differentiation oligodendrocyte cell fate commitment forebrain neuron differentiation cell differentiation neuron differentiation regulation of cell proliferation neuron fate commitment neuron development generation of neurons oligodendrocyte differentiation regulation of neurogenesis positive regulation of neurogenesis regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development enteric nervous system development parasympathetic nervous system development
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