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Invitrogen
ASCT2 Polyclonal Antibody
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FIGURE: 1 / 2
ASCT2 Antibody (PA5-93327) in WB
Western blot was performed using Anti-ASCT2 Polyclonal Antibody (Product # PA5-93327) and a 57 kDa and 80 kDa band corresponding to Neutral amino acid transporter B(0) was observed across cell lines. Whole cell extracts (60 µg lysate) of MCF7 (Lane 1), HT-29 (Lane 2), A549 (Lane 3), T-47D (Lane 4), Hep G2 (Lane 5), BeWo (Lane 6) shown in figure a, and 3T3-L1 (Lane 7), 3T3-L1 (Lane 8) shown in fig b, were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellu... View More
Product Details
PA5-93327
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.52 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: NCI-H460, U-251MG, HepG2; Cellular Location: Cell membrane, Melanosome, Multi-pass membrane protein
Target Information
SLC1A5 (Solute carrier family 1 (neutral amino acid transporter), member 5) is a member of the Na(+)-dependent amino acid transporter superfamily. It has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. It acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; ATB(0); ATB0; Baboon M7 virus receptor; CAZ-associated structural protein; H4-system ASC-like transporter; insulin-activated amino acid transporter; neutral amino acid transporter B; Neutral amino acid transporter B(0); RD114 virus receptor; RD114/simian type D retrovirus receptor; sodium-dependent neutral amino acid transporter ASCT2; Sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 1 member 5; solute carrier family 1, member 7
Gene Aliases: AAAT; ASCT2; ATBO; H4-ASCT2; M7V1; M7VS1; R16; RDR; RDRC; SLC1A5; Slc1a7
UniProt ID: (Human) Q15758
Entrez Gene ID: (Human) 6510, (Rat) 292657, (Mouse) 20514
virus receptor activity
receptor activity
protein binding
amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
L-glutamine transmembrane transporter activity
symporter activity
L-serine transmembrane transporter activity
glutamate binding
sodium:dicarboxylate symporter activity
primary active transporter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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