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Invitrogen
ASH1 Polyclonal Antibody
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Product Details
PA5-144261
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Histone-lysine N-methyltransferase ASH1L protein (1906-2160AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ASH1 (ASH1L) is a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Diseases associated with ASH1 include Mental Retardation, Autosomal Dominant 52 and Pulpitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Absent small and homeotic disks protein 1 homolog; ash1 (absent, small, or homeotic)-like; ASH1-like protein; Histone-lysine N-methyltransferase ASH1L; huASH1; Lysine N-methyltransferase 2H; probable histone-lysine N-methyltransferase ASH1L; unnamed protein product
Gene Aliases: ASH1; ASH1L; ASH1L1; KIAA1420; KMT2H; MRD52
UniProt ID: (Human) Q9NR48
Entrez Gene ID: (Human) 55870
DNA binding
chromatin binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
metal ion binding
histone methyltransferase activity (H3-K9 specific)
histone methyltransferase activity (H3-K36 specific)
histone H3 methyltransferase activity
histone H3K9me2 methyltransferase activity
histone H3K9 monomethyltransferase activity
histone H3K36 trimethyltransferase activity
MAPK cascade
skeletal system development
negative regulation of acute inflammatory response
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
inflammatory response
single fertilization
post-embryonic development
regulation of gene expression
sperm motility
methylation
negative regulation of MAPK cascade
positive regulation of transcription from RNA polymerase II promoter
decidualization
sebaceous gland development
negative regulation of inflammatory response
uterus morphogenesis
tarsal gland development
uterine gland development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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