Search
Proteintech
ASH2L Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
12331-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ASH2L Fusion Protein Ag3008 (329-628 aa encoded by BC015936)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: HGYPLEHPF NKDGYRYILA EPDPHAPDPE KLELDCWAGK PIPGDLYRAC LYERVLLALH DRAPQLKISD DRLTVVGEKG YSMVRASHGV RKGAWYFEIT VDEMPPDTAA RLGWSQPLGN LQAPLGYDKF SYSWRSKKGT KFHQSIGKHY SSGYGQGDVL GFYINLPEDT ETAKSLPDTY KDKALIKFKS YLYFEEKDFV DKAEKSLKQT PHSEIIFYKN GVNQGVAYKD IFEGVYFPAI SLYKSCTVSI NFGPCFKYPP KDLTYRPMSD MGWGAVVEHT LADVLYHVET EVDGRRSPPW EP (329-628 aa encoded by BC015936)
Target Information
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Its predicted molecular weight is 68.7kDa. Alternative splicing results in possible isoforms at 60 kDa & 56.5 kDa). Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. Homology to mouse ASH2L is 90%. ASH2L is predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes as well as leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. Differentiation inducers (e.g. phorbol ester and hemin) cause different expression patterns in these cell lines, suggesting that ASH2L plays a role in hematopoiesis and is associated with particular types of leukemia. In addition ASH2L has been suggested to interact with beta-tubulin and beta-catenin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ASH 2; ash2 (absent, small, or homeotic)-like; ASH2 LIKE; ASH2 like protein; ASH2-like protein; ASH2L; Bre 2; Set1/Ash2 histone methyltransferase complex subunit ASH2; unnamed protein product
Gene Aliases: ASH2; ASH2L; ASH2L1; ASH2L2; Bre2
UniProt ID: (Human) Q9UBL3, (Mouse) Q91X20
Entrez Gene ID: (Human) 9070, (Mouse) 23808
transcription regulatory region sequence-specific DNA binding
DNA binding
protein binding
beta-catenin binding
zinc ion binding
metal ion binding
histone methyltransferase activity (H3-K4 specific)
transcription regulatory region DNA binding
euchromatin binding
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
chromatin organization
cellular response to DNA damage stimulus
positive regulation of cell proliferation
regulation of gene expression
positive regulation of macromolecule biosynthetic process
hemopoiesis
response to estrogen
positive regulation of gene expression, epigenetic
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
positive regulation of transcription from RNA polymerase II promoter
chromatin-mediated maintenance of transcription
histone H3-K4 methylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support