Reconstitute with 100 µL of distilled water.
Centrifuge to remove any insoluble material.
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Interacts with STOM. Interacts with PRKCABP and ACCN3. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACCN; acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; ASIC2; B; BNaC1; BNC1; Brain sodium channel 1; degenerin; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1
Gene Aliases: ACCN; ACCN1; ACIC2; ASIC2; ASIC2a; BNAC1; BNaC1a; BNC1; BNC1k; hBNaC1; MDEG; MDEG1; MDEG2