Invitrogen

ASIC2 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details

View all (6) ASIC2 antibodies

Datasheet

Questions & Answers

Datasheet

Questions & Answers

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ASIC2 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of ASIC2 in human cerebral cortex and kidney tissues using ASIC2 Polyclonal Antibody (Product # PA5-62554). Corresponding ASIC2 RNA-seq data are presented for the same tissues.

ASIC2 Antibody in Western Blot (WB) — Western blot analysis of ASIC2 in control (vector only transfected HEK293T lysate) and ASIC2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a ASIC2 Polyclonal Antibody (Product # PA5-62554).

ASIC2 Antibody in Relative expression — Relative expression in different tissues in IHC: Detection of differential expression levels of ASIC2 demonstrates antibody specificity. Immunohistochemical analysis of ASIC2 using anti-ASIC2 Polyclonal Antibody (Product # PA5-62554), shows significant staining of ASIC2 in human cerebral cortex and shows minimal or weak staining in human kidney tissues. The relative expression levels of ASIC2 within each tissue is shown using RNA-Seq. {RE}

Product Details

Tested Applications

Dilution

Immunohistochemistry (IHC)

1:200-1:500

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ASIC2

Conjugate

Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2638291

Product Specific Information

Immunogen sequence: LLDVNLQIPD PHLADPSVLE ALRQKANFKH YKPKQFSMLE FLHRVGHDLK DMMLYCKFKG QECGHQDFTT VFTKY

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 51%.

Target Information

ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ACCN; acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; ASIC2; ASIC2a; BNaC1; BNC1; Brain sodium channel 1; hBNaC1; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1

Gene Aliases: ACCN; ACCN1; ASIC2; ASIC2a; BNAC1; BNC1; hBNaC1; MDEG

UniProt ID: (Human) Q16515

Entrez Gene ID: (Human) 40

Molecular Function: ion channel transporter